Michael Hughes

TL;DR: Genotypic resistance at codon 215 in plasma HIV RNA is associated with the subsequent immunologic and virologic failure of ZDV monotherapy in subjects with 200 to 500 CD4 cells/mm3.

TL;DR: Socially disadvantaged pregnant women with HIV, who are at greater risk for having detectable viral load at delivery, may benefit from interventions to promote early prenatal care, early HAART initiation, and medication adherence.

TL;DR: In this study, significant bacteriuria defined a specific sub-group of PBC patients with an increased risk of death, particularly those with late stage disease on liver biopsy.

TL;DR: The NIAID-sponsored workshop on statistical issues for HIV surrogate endpoints as discussed by the authors explored a series of specific questions dealing with the relationship between markers and clinical endpoints, and the choice of endpoints and methods of analysis in clinical studies.

TL;DR: In this population of children with HIV, total lymphocyte count was a strong predictor of short-term disease progression, being only marginally less predictive than CD4-cell percentage, and when the markers were compared at the threshold values at which mortality risks were about equal, this resulted in an earlier start of antiretroviral therapy.