M
Michael Hughes
Researcher at Royal Hallamshire Hospital
Publications - 615
Citations - 26328
Michael Hughes is an academic researcher from Royal Hallamshire Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 74, co-authored 531 publications receiving 24066 citations. Previous affiliations of Michael Hughes include Royal College of Physicians & St Thomas' Hospital.
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Journal ArticleDOI
Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters.
Denise M. Gaughan,Denise M. Gaughan,Paul D. Siegel,Michael Hughes,Chiung-yu Chang,Brandon F. Law,Corey R. Campbell,Jennifer C. Richards,Stefanos F. Kales,Marcia Chertok,Lester Kobzik,Phuong-son Nguyen,Carl R. O'Donnell,Max Kiefer,Gregory R. Wagner,David C. Christiani +15 more
TL;DR: Higher mean lower respiratory symptom score was associated with lower percent predicted forced expiratory volume in one second/forced vital capacity and biomarkers of oxidative stress may serve as indicators of arterial stiffness in wildland firefighters.
Journal ArticleDOI
The synthesis and secretion of ribosomes by nurse cells of Antheraea polyphemus
TL;DR: A technique is described for isolating the three component cell-types that make up the ovarian follicle of the giant silkmoth, Antheraea polyphemus, and the synthetic products of one of these cell types, the highly polyploid nurse cells, were examined in detail by density gradient centrifugation.
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Reporting bayesian analyses of clinical trials
TL;DR: This work focuses on two types of prior that deserve consideration, the first of which is the non-informative prior giving standardized likelihood distributions as post-trial probability distributions and the second which has a spike of probability mass at the point of no treatment effect.
Journal ArticleDOI
HIV transmission and 24-month survival in a randomized trial of HAART to prevent MTCT during pregnancy and breastfeeding in Botswana.
Roger L. Shapiro,Douglas Kitch,Anthony Ogwu,Michael Hughes,Shahin Lockman,Kathleen M. Powis,Sajini Souda,Claire Moffat,Sikhulile Moyo,Kenneth McIntosh,Erik van Widenfelt,Sheryl Zwerski,Loeto Mazhani,Joseph Makhema,Max Essex +14 more
TL;DR: Disease progression appeared slower after discontinuing protease inhibitor-based HAART, but a concerning number of maternal deaths occurred after stopping either regimen.
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Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021.
Ross E. McKinney,John H. Rodman,Chengcheng Hu,Paula Britto,Michael Hughes,Mary E. Smith,Leslie Serchuck,Joyce Kraimer,Alberto A. Ortiz,Patricia M. Flynn,Ram Yogev,Stephen A. Spector,Linda Draper,Paul Tran,Melissa Scites,Ruth Dickover,Adriana Weinberg,Coleen K. Cunningham,Coleen K. Cunningham,Elaine J. Abrams,M. Robert Blum,Gregory E. Chittick,Laurie Reynolds,Mobeen H. Rathore +23 more
TL;DR: A once-daily regimen of emtricitabine, didanosine, and efavirenz proved to be safe and tolerable and demonstrated good immunologic and virologic efficacy in this 2-year study.