Michael Hughes

TL;DR: In this study, HIV-infected African women starting a NVP-based antiretroviral regimen had a lower NVP clearance compared to previous reports, and baseline CD4 cell count at least 250 cells/&mgr;l was significantly associated with NVP toxicity.

TL;DR: Losses to follow-up probably decreased substantially the observed number of primary endpoints, curtailed the power of the trial to demonstrate any difference between immediate and deferred initiation of antiretroviral therapy, and may have introduced large bias in the estimated hazard ratio for the primary endpoint and its statistical significance.

TL;DR: The results further delineate the prognostic significance of HIV-1 RNA and CD4+ cell count and should help to better define their utility in the practice setting.

TL;DR: Michael Hughes and Paige Williams discuss the complex questions concerning both the potential confounding of risk associations and the mechanisms by which treatment might cause an adverse effect.

TL;DR: Using a hand-crafted clustering technique, Hughes and Peterson as discussed by the authors identified eight patterns of cultural choice in a national survey collected in 1973 and found that the resulting patterns cannot be arranged in hierarchical order by social class, bringing into question the hypothesized association between culture class and social class.