Mikko Vuorela

TL;DR: It is suggested that loss-of-function mutations in RAD 51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.

TL;DR: A full mutation screening of the RAD51C gene in 147 Finnish familial breast cancer cases and in 232 unselected ovarian cancer cases originating from Finland and Sweden confirms that RAD 51C mutations are implicated in breast and ovarian cancer predisposition, although their overall frequency seems to be low.

TL;DR: It is suggested that rare CNVs represent an alternative source of genetic variation influencing hereditary risk for breast cancer, and are closely related to estrogen signaling and TP53 centered tumor suppressor network.

TL;DR: This study characterized the β4-integrin interacting proteome using BioID proximity-dependent biotinylation in epithelial MDCK cells and identified several novel type II hemidesmosome (HD)-associated proteins and revealed potential connecting protein modules that could orchestrate the observed coordinated coassembly of HDs and focal adhesions.

TL;DR: It seems unlikely that any constitutional changes in MRG15 confer an increased risk for breast cancer, as seven previously unreported variants were identified but in silico analyses revealed that none of these variants appears to modify the function of MRG 15.