M
Min Ru Qiu
Researcher at St. Vincent's Health System
Publications - 34
Citations - 1458
Min Ru Qiu is an academic researcher from St. Vincent's Health System. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 15, co-authored 27 publications receiving 1339 citations. Previous affiliations of Min Ru Qiu include Garvan Institute of Medical Research & University of New South Wales.
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Journal ArticleDOI
PI3K pathway activation in breast cancer is associated with the basal‐like phenotype and cancer‐specific mortality
Elena Lopez-Knowles,Sandra A O'Toole,Catriona M. McNeil,Catriona M. McNeil,Ewan K.A. Millar,Min Ru Qiu,Min Ru Qiu,Paul Crea,Roger J. Daly,Roger J. Daly,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Robert L. Sutherland,Robert L. Sutherland +13 more
TL;DR: It is concluded that >70% of breast cancers have an alteration in at least 1 component of the PI3K pathway and this might be exploited to therapeutic advantage especially in “basal‐like” cancers.
Journal ArticleDOI
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.
Stephen J. Harrop,Matthew Z. DeMaere,W.D. Fairlie,T. Reztsova,Stella M. Valenzuela,Michele Mazzanti,Raffaella Tonini,Min Ru Qiu,Lucy Jankova,Kristina Warton,Asne R. Bauskin,W.M. Wu,S. Pankhurst,Terence J. Campbell,Samuel N. Breit,Paul M. G. Curmi +15 more
TL;DR: The structure indicates that CLIC1 is likely to be controlled by redox-dependent processes.
Journal ArticleDOI
Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
Sandra A O'Toole,Dorothy A Machalek,Robert F. Shearer,Ewan K.A. Millar,Radhika Nair,Peter R. Schofield,Duncan J. Mcleod,Caroline L. Cooper,Catriona M. McNeil,Andrea McFarland,Akira Nguyen,Christopher J. Ormandy,Min Ru Qiu,Brian Rabinovich,Luciano G. Martelotto,Duc Vu,Gregory E. Hannigan,Elizabeth A. Musgrove,Daniel Christ,Robert L. Sutherland,D. Neil Watkins,Alexander Swarbrick +21 more
TL;DR: In a cohort of 279 patients with invasive ductal carcinoma of the breast, expression of Hh ligand was significantly associated with increased risk of metastasis, breast cancer-specific death, and a basal-like phenotype, and paracrine signature was an independent predictor for overall survival in multivariate analysis.
Journal ArticleDOI
The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.
Stella M. Valenzuela,Michele Mazzanti,Raffaella Tonini,Min Ru Qiu,Kristina Warton,Elizabeth A. Musgrove,Terence J. Campbell,Samuel N. Breit +7 more
TL;DR: It is demonstrated that Cl− ion channel blockers known to block NCC27 led to arrest of CHO‐K1 cells in the G2/M stage of the cell cycle, the same stage at which this ion channel is selectively expressed on the plasma membrane.
Journal ArticleDOI
Recombinant CLIC1 (NCC27) Assembles in Lipid Bilayers via a pH-dependent Two-state Process to Form Chloride Ion Channels with Identical Characteristics to Those Observed in Chinese Hamster Ovary Cells Expressing CLIC1 *
Kristina Warton,Raffaella Tonini,W. Douglas Fairlie,Jacqueline M. Matthews,Stella M. Valenzuela,Min Ru Qiu,Wan Man Wu,S. Pankhurst,Asne R. Bauskin,Stephen J. Harrop,Terence J. Campbell,Paul M. G. Curmi,Samuel N. Breit,Michele Mazzanti +13 more
TL;DR: This work indicates that the CLIC1 ion channel is likely to consist of a tetrameric assembly of subunits and indicates that despite its size and unusual properties, it is able to form a completely functional ion channel in the absence of any other ancillary proteins.