N
Naohiko Seki
Researcher at Chiba University
Publications - 391
Citations - 20245
Naohiko Seki is an academic researcher from Chiba University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 74, co-authored 381 publications receiving 18648 citations. Previous affiliations of Naohiko Seki include Toho University & National Institute of Radiological Sciences.
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Journal ArticleDOI
MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology
Yasutoshi Yamada,Hideki Enokida,Satoko Kojima,Kazumori Kawakami,Takeshi Chiyomaru,Shuichi Tatarano,Hirofumi Yoshino,Kazuya Kawahara,Kenryu Nishiyama,Naohiko Seki,Masayuki Nakagawa +10 more
TL;DR: MiR‐96 and miR‐183 in urine are promising tumor markers for UC and may be a good diagnostic marker in combination with urinary cytology.
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Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase ( PNP ) in prostate cancer
Satoko Kojima,Takeshi Chiyomaru,Kazumori Kawakami,Hirofumi Yoshino,Hideki Enokida,Nijiro Nohata,Miki Fuse,Tomohiko Ichikawa,Yukio Naya,Masayuki Nakagawa,Naohiko Seki +10 more
TL;DR: The PNP is a novel target gene of both miRNAs and potentially functions as an oncogene and may provide new insights into the underlying causes of PCa oncogenesis, which is a frequent event in PCa and both function as tumour suppressors.
Genistein Inhibits Prostate Cancer Cell Growth by Targeting miR-34a and Oncogenic HOTAIR
Takeshi Chiyomaru,Soichiro Yamamura,Shinichiro Fukuhara,Hirofumi Yoshino,Takashi Kinoshita,Shahana Majid,Sharanjot Saini,Inik Chang,Yuichiro Tanaka,Hideki Enokida,Naohiko Seki,Masayuki Nakagawa,Rajvir Dahiya +12 more
TL;DR: Genistein is a soy isoflavone that has antitumor activity both in vitro and in vivo as mentioned in this paper, it has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by regulating several cell signaling pathways and microRNAs (miRNA).
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Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.
TL;DR: Five known and nine new genes for proteins with multiple EGF-like-motifs from 8000 redundant human brain cDNA clones are identified, demonstrating that motif-trap screening is a powerful tool for the discovery of new genes that have been difficult to identify by conventional methods.
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Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma
Hideo Hidaka,Naohiko Seki,Hirofumi Yoshino,Takeshi Yamasaki,Yasutoshi Yamada,Nijiro Nohata,Miki Fuse,Masayuki Nakagawa,Hideki Enokida +8 more
TL;DR: Downregulation of tumor suppressive miR-1285, which targets oncogenic genes including TGM2, might contribute to RCC development and provides new insights into potential mechanisms of RCC oncogenesis.