N
Naohiko Seki
Researcher at Chiba University
Publications - 391
Citations - 20245
Naohiko Seki is an academic researcher from Chiba University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 74, co-authored 381 publications receiving 18648 citations. Previous affiliations of Naohiko Seki include Toho University & National Institute of Radiological Sciences.
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Journal ArticleDOI
Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer.
Takeshi Chiyomaru,Naohiko Seki,Satoru Inoguchi,Tomoaki Ishihara,Hiroko Mataki,Ryosuke Matsushita,Yusuke Goto,Rika Nishikawa,Shuichi Tatarano,Toshihiko Itesako,Masayuki Nakagawa,Hideki Enokida +11 more
TL;DR: It is concluded that the decreased expression of the tumor-suppressive miR-23b/27b cluster enhanced cancer cell proliferation, migration and invasion in BC through direct regulation of EGFR and c-Met signaling pathways.
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Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance.
Yasutaka Yamada,Takayuki Arai,Satoko Kojima,Sho Sugawara,Mayuko Kato,Atsushi Okato,Kazuto Yamazaki,Yukio Naya,Tomohiko Ichikawa,Naohiko Seki +9 more
TL;DR: Functional assays showed that miR‐144‐5p and miR-144‐3p significantly reduced cancer cell migration and invasive abilities, suggesting these miRNAs acted as antitumor miRN as well as putative oncogenic targets in RCC cells.
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p73, a gene related to p53, is not mutated in esophageal carcinomas.
Yoshinori Nimura,Motohiro Mihara,Shingo Ichimiya,Shigeru Sakiyama,Naohiko Seki,Miki Ohira,Nobuo Nomura,Minoru Fujimori,Wataru Adachi,Jun Amano,Ming He,Yu-Min Ping,Akira Nakagawara +12 more
TL;DR: The results suggest that, at least in esophageal carcinomas, allelic loss or mutation of p73 may not be a main genetic event for the tumorigenesis as it is with p53.
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Identification of novel molecular targets regulated by tumor suppressive miR-1/miR-133a in maxillary sinus squamous cell carcinoma
Nijiro Nohata,Toyoyuki Hanazawa,Naoko Kikkawa,Daiju Sakurai,Keita Sasaki,Takeshi Chiyomaru,Kazumori Kawakami,Hirofumi Yoshino,Hideki Enokida,Masayuki Nakagawa,Yoshitaka Okamoto,Naohiko Seki +11 more
TL;DR: Restoration of downregulated mi RNAs (miR-1 or miR-133a) in cancer cells revealed that both miRNAs significantly inhibited cancer cell proliferation and induced cell apoptosis and identification of the novel cancer networks regulated by these miRNas in MSSCC was revealed.
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cDNA Microarray Analysis of Helicobacter pylori-Mediated Alteration of Gene Expression in Gastric Cancer Cells
Shin Maeda,Motoyuki Otsuka,Yoshihiro Hirata,Yuzo Mitsuno,Haruhiko Yoshida,Yasushi Shiratori,Yasuhiko Masuho,Masaaki Muramatsu,Naohiko Seki,Masao Omata +9 more
TL;DR: Results indicate the importance of microarray technology as a tool for analyzing the complex interplay between H. pylori and the host.