N
Naohiko Seki
Researcher at Chiba University
Publications - 391
Citations - 20245
Naohiko Seki is an academic researcher from Chiba University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 74, co-authored 381 publications receiving 18648 citations. Previous affiliations of Naohiko Seki include Toho University & National Institute of Radiological Sciences.
Papers
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Role of pre-miR-532 (miR-532-5p and miR-532-3p) in regulation of gene expression and molecular pathogenesis in renal cell carcinoma.
Yasutaka Yamada,Takayuki Arai,Mayuko Kato,Satoko Kojima,Shinichi Sakamoto,Akira Komiya,Yukio Naya,Tomohiko Ichikawa,Naohiko Seki +8 more
TL;DR: This study investigated the functional significance of these miRNAs and identified gene targets involved in RCC pathogenesis and found that AQP9 expression is an independent prognostic factor for RCC patients, and siRNA-mediated knockdown of AQP 9 by si-AQP9 inhibited the malignant phenotypes of RCC cells.
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Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2.
M Nagai,Shingo Ichimiya,Toshinori Ozaki,Naohiko Seki,Motohiro Mihara,Shigeyuki Furuta,Miki Ohira,Nobumoto Tomioka,N Nomura,Shigeru Sakiyama,O. Kubo,K Takakura,Tada-aki Hori,Akira Nakagawara +13 more
TL;DR: The full-length KIAA0591 gene may be a novel member of human KIF superfamily which lacks motor domain and might function as a tumor suppressor in an epigenetic but not a classic Knudson's manner.
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Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: miR-320 family-regulated molecular pathways and targets.
Takayuki Arai,Miki Fuse,Yusuke Goto,Kanya Kaga,Akira Kurozumi,Yasutaka Yamada,Sho Sugawara,Atsushi Okato,Tomohiko Ichikawa,Tomonori Yamanishi,Naohiko Seki +10 more
TL;DR: Novel approaches that identify aberrantly expressed miRNA regulatory networks in IC could provide new prognostic markers and therapeutic targets for this disease.
Patent
New full length cdna
Takao Isogai,磯貝 隆夫,Tomoyasu Sugiyama,杉山 友康,Tetsutsugu Otsuki,大槻 哲嗣,Ai Wakamatsu,若松 愛,Hiroyuki Sato,佐藤 寛之,Shizuko Ishii,石井 静子,Junichi Yamamoto,山本 順一,Yuko Isono,五十野 祐子,Yumitoshi Hio,肥尾 弓利,Kaoru Otsuka,大塚 薫,Keiichi Nagai,永井 啓一,Ryotaro Irie,入江 亮太郎,Ichiro Tamechika,為近 一郎,Naohiko Seki,関 直彦,Tsutomu Yoshikawa,吉川 勉,Motoyuki Otsuka,大塚 基之,Kenji Nagahari,長張 健二,Masuyasu Yasuhiko,増保 安彦,Daichi Naka,仲 大地,Kunji Kawai,河合 勲二,Katsuhiko Suzuki,鈴木 克彦,Hiroshi Nakano,中野 浩史,Atsushi Kondo,近藤 淳,Hashimoto Hidemi,橋本 秀美,Shiratori Yoshikazu,白鳥 美和 +49 more
TL;DR: In this paper, the full-length base sequence of the cDNA, and the amino acid sequence encoded by the base sequence are disclosed, which is useful for the therapy and diagnosis of various kinds of diseases.
Journal ArticleDOI
Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif
Naohiko Seki,Atsushi Hattori,Sumio Sugano,Yutaka Suzuki,Akira Nakagawara,Miki Ohhira,Masaaki Muramatsu,Tada-aki Hori,Toshiyuki Saito +8 more
TL;DR: A novel gene encoding a RING finger (C3HC4-type zinc finger) protein from a human neuroblastoma full-length enriched cDNA library is identified and the chromosomal location of the gene was determined on the chromosome 6p21.3 region.