N
Naohiko Seki
Researcher at Chiba University
Publications - 391
Citations - 20245
Naohiko Seki is an academic researcher from Chiba University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 74, co-authored 381 publications receiving 18648 citations. Previous affiliations of Naohiko Seki include Toho University & National Institute of Radiological Sciences.
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The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes.
Keiko Mizuno,Hiroko Mataki,Takayuki Arai,Atsushi Okato,Kazuto Kamikawaji,Tomohiro Kumamoto,Tsubasa Hiraki,Kazuhito Hatanaka,Hiromasa Inoue,Naohiko Seki +9 more
TL;DR: A microRNA (miRNA) expression signature of SCLC is constructed by analysis of autopsy specimens and it is demonstrated that ectopic expression of both miR-27a-5p andMiR-34b-3p significantly inhibited cancer cell aggressiveness.
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Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.
Yusuke Goto,Rika Nishikawa,Satoko Kojima,Takeshi Chiyomaru,Hideki Enokida,Satoru Inoguchi,Takashi Kinoshita,Miki Fuse,Shinichi Sakamoto,Masayuki Nakagawa,Yukio Naya,Tomohiko Ichikawa,Naohiko Seki +12 more
TL;DR: It is concluded that loss of tumour‐suppressive miR‐224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52.
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The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma
Yusuke Goto,Akira Kurozumi,Nijiro Nohata,Satoko Kojima,Ryosuke Matsushita,Hirofumi Yoshino,Kazuto Yamazaki,Yasuo Ishida,Tomohiko Ichikawa,Yukio Naya,Naohiko Seki +10 more
TL;DR: It is shown that antitumor miR-101- mediated UHRF1 pathways may be suppressed by sunitinib treatment, and the pathways of nucleotide excision repair and mismatch repair were significantly suppressed by knockdown of U HRF1.
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MicroRNAs in non-small cell lung cancer and idiopathic pulmonary fibrosis.
TL;DR: This review summarizes current knowledge on aberrantly expressed miRNAs regulating NSCLC and IPF based on miRNA expression signatures to improve understanding of the molecular mechanisms of these diseases.
Journal ArticleDOI
Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma
Tetsuya Idichi,Naohiko Seki,Hiroshi Kurahara,Keiichi Yonemori,Yusaku Osako,Takayuki Arai,Atsushi Okato,Yoshiaki Kita,Takaaki Arigami,Yuko Mataki,Yuko Kijima,Kosei Maemura,Shoji Natsugoe +12 more
TL;DR: Identification of antitumor miR-217/ANLN-mediated PDAC pathways will provide new insights into the potential mechanisms underlying the aggressive course of PDAC.