N
Naohiko Seki
Researcher at Chiba University
Publications - 391
Citations - 20245
Naohiko Seki is an academic researcher from Chiba University. The author has contributed to research in topics: microRNA & Cancer. The author has an hindex of 74, co-authored 381 publications receiving 18648 citations. Previous affiliations of Naohiko Seki include Toho University & National Institute of Radiological Sciences.
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Journal ArticleDOI
Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
Sandeep Potluri,Salam A. Assi,Paulynn Suyin Chin,Dan J.L. Coleman,Anna Pickin,Shogo Moriya,Naohiko Seki,Olaf Heidenreich,Peter N. Cockerill,Constanze Bonifer +9 more
TL;DR: It is shown that the transcription factor WT1 forms a major node in the rewired mutation-specific gene regulatory networks of multiple AML subtypes and plays a central and widespread role in AML biology.
Journal ArticleDOI
Induction of a BrdU-enhanceable fragile site-like lesion and sister chromatid exchanges at 11q23.1 in EBV-transformed lymphoblastoid cell lines.
Naohiko Seki,H. Tsuji,Ei Ichi Takahashi,M. Yamauchi,Toshiyuki Saito,T. Hashimoto,K. Yamamoto,Tada-aki Hori +7 more
TL;DR: The expression of a fragile site-like lesion and induction of sister chromatid exchanges (SCEs) at 11q23.1 in EBV-transformed lymphoblastoid cell lines derived from carriers of distamycin A-inducible fragile sites and ataxia telangiectasia patients were examined.
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Expression of the WT1 gene -KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells.
TL;DR: Findings suggest that the -KTS-containing variants of WT1 are directly involved in the regulation of p21(Waf1/Cip1) expression and the subsequent suppression of lymph node metastasis in human lung squamous cell carcinoma.
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Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma
Nozomi Tanaka,Chikashi Minemura,Shunichi Asai,Naoko Kikkawa,Takashi Kinoshita,Sachi Oshima,Ayaka Koma,Atsushi Kasamatsu,Toyoyuki Hanazawa,Katsuhiro Uzawa,Naohiko Seki +10 more
TL;DR: In this article, the authors identify cancer-promoting genes commonly regulated by miR-199-5p and miR199-3p in head and neck squamous cell carcinoma (HNSCC) cells.
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Integrated analysis of expression and genome alteration reveals putative amplified target genes in esophageal cancer
TL;DR: To identify putative amplification target genes in esophageal cancer, a survey of parallel DNA copy number and gene expression in 10 esophagingal squamous cell carcinoma cell lines revealed a set of 97 genes with elevated expression levels that were attributable to increased copy number.