N
Narcis Fernandez-Fuentes
Researcher at Aberystwyth University
Publications - 96
Citations - 2629
Narcis Fernandez-Fuentes is an academic researcher from Aberystwyth University. The author has contributed to research in topics: Protein structure & Antimicrobial peptides. The author has an hindex of 25, co-authored 88 publications receiving 2145 citations. Previous affiliations of Narcis Fernandez-Fuentes include University of Leeds & University of Vic.
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Journal ArticleDOI
Insights into the mechanism of microtubule stabilization by Taxol
Hui Xiao,Pascal Verdier-Pinard,Narcis Fernandez-Fuentes,Berta Burd,Ruth Hogue Angeletti,Andras Fiser,Susan Band Horwitz,George A. Orr +7 more
TL;DR: In this article, the structural changes occurring in both β- and α-tubulin upon microtubule stabilization by Taxol were analyzed and shown to be distinct from and complementary to that due to GTP-induced polymerization.
Journal ArticleDOI
ArchPRED: a template based loop structure prediction server
TL;DR: In a head to head comparison on loops extracted from freshly deposited new protein folds the current method outperformed in a ∼5:1 ratio an earlier developed database search method.
Journal ArticleDOI
Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experiment.
Marc F. Lensink,Sameer Velankar,Andriy Kryshtafovych,Shen You Huang,Dina Schneidman-Duhovny,Andrej Sali,Joan Segura,Narcis Fernandez-Fuentes,Shruthi Viswanath,Ron Elber,Sergei Grudinin,Petr Popov,Emilie Neveu,Hasup Lee,Minkyung Baek,Sangwoo Park,Lim Heo,Gyu Rie Lee,Chaok Seok,Sanbo Qin,Huan-Xiang Zhou,David W. Ritchie,Bernard Maigret,Marie-Dominique Devignes,Anisah W. Ghoorah,Mieczyslaw Torchala,Raphael A. G. Chaleil,Paul A. Bates,Efrat Ben-Zeev,Miriam Eisenstein,Surendra S. Negi,Zhiping Weng,Thom Vreven,Brian G. Pierce,Tyler M. Borrman,Jinchao Yu,Françoise Ochsenbein,Raphael Guerois,Anna Vangone,João P. G. L. M. Rodrigues,Gydo C. P. van Zundert,Mehdi Nellen,Li C. Xue,Ezgi Karaca,Adrien S. J. Melquiond,Koen M. Visscher,Panagiotis L. Kastritis,Alexandre M. J. J. Bonvin,Xianjin Xu,Liming Qiu,Chengfei Yan,Jilong Li,Zhiwei Ma,Jianlin Cheng,Xiaoqin Zou,Yang Shen,Lenna X. Peterson,Hyung Rae Kim,Amit Roy,Amit Roy,Xusi Han,Juan Esquivel-Rodríguez,Daisuke Kihara,Xiaofeng Yu,Neil J. Bruce,Jonathan C. Fuller,Rebecca C. Wade,Ivan Anishchenko,Petras J. Kundrotas,Ilya A. Vakser,Kenichiro Imai,Kazunori D. Yamada,Toshiyuki Oda,Tsukasa Nakamura,Kentaro Tomii,Chiara Pallara,Miguel Romero-Durana,Brian Jiménez-García,Iain H. Moal,Juan Fernández-Recio,Jong Young Joung,Jong Yun Kim,Keehyoung Joo,Jooyoung Lee,Jooyoung Lee,Dima Kozakov,Sandor Vajda,Scott E. Mottarella,David R. Hall,Dmitri Beglov,Artem B. Mamonov,Bing Xia,Tanggis Bohnuud,Carlos A. Del Carpio,Carlos A. Del Carpio,Eichiro Ichiishi,Nicholas A. Marze,Daisuke Kuroda,Shourya S. Roy Burman,Jeffrey J. Gray,Edrisse Chermak,Luigi Cavallo,Romina Oliva,Andrey Tovchigrechko,Shoshana J. Wodak +104 more
TL;DR: Results show that the prediction of homodimer assemblies by homology modeling techniques and docking calculations is quite successful for targets featuring large enough subunit interfaces to represent stable associations, and that docking procedures tend to perform better than standard homology modeled techniques.
Journal ArticleDOI
M4T: a comparative protein structure modeling server.
Narcis Fernandez-Fuentes,Carlos J. Madrid-Aliste,Brajesh K. Rai,J. Eduardo Fajardo,Andras Fiser +4 more
TL;DR: The performance of M4T was benchmarked on CASP6 comparative modeling target sequences and on a larger independent test set and showed a favorable performance to current state-of-the-art methods.
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A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
Houman Ashrafian,Louise Docherty,Vincenzo C. Leo,Christopher Towlson,Monica Neilan,Violetta Steeples,Craig A. Lygate,Tertius Hough,Stuart Townsend,Debbie Williams,Sara Wells,D. P. Norris,Sarah Glyn-Jones,John M. Land,Ivana Barbaric,Zuzanne Lalanne,Paul Denny,Dorota Szumska,Shoumo Bhattacharya,Julian L. Griffin,Iain P. Hargreaves,Narcis Fernandez-Fuentes,Michael Cheeseman,Hugh Watkins,T. Neil Dear,T. Neil Dear,T. Neil Dear +26 more
TL;DR: This is the first demonstration that a defect in a gene involved in mitochondrial remodelling can result in cardiomyopathy, showing that the function of this gene is needed for the maintenance of normal cellular function in a relatively tissue-specific manner.