Tyler M. Borrman

TL;DR: This study shows that neural differentiation is associated with highly cell type–specific 3DG remodeling, which is paralleled by an expansion of3DG space associated with SZ risk, and tests whether the neural cell–specific SZ-related “chromosomal connectome” showed evidence of coordinated transcriptional regulation and proteomic interaction of the participating genes.

TL;DR: Results show that the prediction of homodimer assemblies by homology modeling techniques and docking calculations is quite successful for targets featuring large enough subunit interfaces to represent stable associations, and that docking procedures tend to perform better than standard homology modeled techniques.

TL;DR: CAPRI Round 46 indicates that residues in binding interfaces were less well predicted in this set of targets than in previous Rounds, providing useful insights for directions of future improvements.

TL;DR: It is shown for the first time in vivo that multiple MCMs are loaded at origins, which provides a mechanistic explanation for the observed heterogeneity in origin firing and helps to explain how defined replication timing profiles emerge from stochastic origin firing.

TL;DR: It is shown how the TCR specificity/cross-reactivity duality can be rationalized from structural and biophysical principles, and how these same principles can also explain amino acid preferences in immunogenic epitopes and highlight opportunities for structural considerations in predictive immunology.