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Nobuhiko Kayagaki
Researcher at Genentech
Publications - 36
Citations - 11664
Nobuhiko Kayagaki is an academic researcher from Genentech. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 24, co-authored 36 publications receiving 8766 citations. Previous affiliations of Nobuhiko Kayagaki include Juntendo University.
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Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
Journal ArticleDOI
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki,Søren Warming,Mohamed Lamkanfi,Lieselotte Vande Walle,Salina Louie,Jennifer Dong,Kim Newton,Yan Qu,Jinfeng Liu,Sherry Heldens,Juan Zhang,Wyne P. Lee,Merone Roose-Girma,Vishva M. Dixit +13 more
TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
Journal ArticleDOI
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
Nobuhiko Kayagaki,Michael Wong,Irma B. Stowe,Sree R. Ramani,Lino C. Gonzalez,Sachiko Akashi-Takamura,Kensuke Miyake,Juan Zhang,Wyne P. Lee,Artur Muszyński,Lennart S. Forsberg,Russell W. Carlson,Vishva M. Dixit +12 more
TL;DR: It is shown that macrophages loaded with synthetic lipid A, E. coli lipopolysaccharide (LPS), or S. typhimurium LPS activate caspase-11 independently of the LPS receptor Toll-like receptor 4 (TLR4), revealing a TLR4-independent mechanism for innate immune recognition of LPS.
Journal ArticleDOI
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
Eugene Varfolomeev,John W. Blankenship,Sarah M. Wayson,Anna V. Fedorova,Nobuhiko Kayagaki,Parie Garg,Kerry Zobel,Jasmin N. Dynek,Linda O. Elliott,Heidi J.A. Wallweber,John A. Flygare,Wayne J. Fairbrother,Kurt Deshayes,Vishva M. Dixit,Domagoj Vucic +14 more
TL;DR: It is demonstrated that small-molecule IAP antagonists bind to select baculovirus IAP repeat (BIR) domains resulting in dramatic induction of auto-ubiquitination activity and rapid proteasomal degradation of c-IAPs.
Journal ArticleDOI
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
Robin A. Aglietti,Alberto Estevez,Aaron Gupta,Monica Gonzalez Ramirez,Peter Liu,Nobuhiko Kayagaki,Claudio Ciferri,Vishva M. Dixit,Erin C. Dueber +8 more
TL;DR: The mouse I105N/human I104N mutation, which has been shown to prevent macrophage pyroptosis, attenuated both cell killing by p30 in a 293T transient overexpression system and membrane permeabilization in vitro, suggesting that the mutants are actually hypomorphs, but must be above certain concentration to exhibit activity.