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Nobuyo Tsuboyama-Kasaoka
Publications - 64
Citations - 7494
Nobuyo Tsuboyama-Kasaoka is an academic researcher. The author has contributed to research in topics: Medicine & Dietary Reference Intake. The author has an hindex of 19, co-authored 56 publications receiving 7098 citations.
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Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
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Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice.
Nobuyo Tsuboyama-Kasaoka,Mayumi Takahashi,Kentaro Tanemura,Hyounju Kim,Tsuyoshi Tange,Hitoshi Okuyama,Masaaki Kasai,Shinji Ikemoto,Osamu Ezaki +8 more
TL;DR: It is demonstrated that intake of CLA reduces adipose tissue by apoptosis and results in lipodystrophy, but hyperinsulinemia by CLA can be normalized by leptin administration.
Journal ArticleDOI
Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes
Toshimasa Yamauchi,Hironori Waki,Junji Kamon,Koji Murakami,Kiyoto Motojima,Kajuro Komeda,Hiroshi Miki,Naoto Kubota,Yasuo Terauchi,Atsuko Tsuchida,Nobuyo Tsuboyama-Kasaoka,Naoko Yamauchi,Tomohiro Ide,Wataru Hori,Shigeaki Kato,Masashi Fukayama,Yasuo Akanuma,Osamu Ezaki,Akiko Itai,Ryozo Nagai,Satoshi Kimura,Kazuyuki Tobe,Hiroyuki Kagechika,Koichi Shudo,Takashi Kadowaki +24 more
TL;DR: It is shown that an RXR antagonist and a PPARgamma antagonist decrease triglyceride (TG) content in white adipose tissue, skeletal muscle, and liver, thereby ameliorating HF diet-induced obesity and insulin resistance.
Journal ArticleDOI
Taurine (2-Aminoethanesulfonic Acid) Deficiency Creates a Vicious Circle Promoting Obesity
Nobuyo Tsuboyama-Kasaoka,Chikako Shozawa,Kayo Sano,Yasutomi Kamei,Seiichi Kasaoka,Yu Hosokawa,Osamu Ezaki +6 more
TL;DR: Dietary taurine supplementation prevented high-fat diet-induced obesity with increased resting energy expenditure and interrupted a vicious circle promoting obesity.
Journal ArticleDOI
Fish oil feeding alters liver gene expressions to defend against PPARα activation and ROS production
Mayumi Takahashi,Nobuyo Tsuboyama-Kasaoka,Teruyo Nakatani,Masami Ishii,Shuichi Tsutsumi,Hiroyuki Aburatani,Osamu Ezaki +6 more
TL;DR: Analysis of gene expression profile of mice liver indicates that fish oil feeding downregulated the endogenous PPARalpha-activation system and increased antioxidant gene expressions to protect against ROS excess.