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TL;DR: It is shown how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals and suggested that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.

TL;DR: Trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T2D progressors from nonprogressors are identified.

TL;DR: It is indicated that a lipid signature characteristic of type 2 diabetes mellitus is present years before the diagnosis and improves prediction of progression to T2DM.

TL;DR: This study is the first systems‐level resource combining data from genomewide transcriptomics with global quantitative proteomics and untargeted metabolomics analyses in the mouse heart throughout the early postnatal period, providing evidence that the mevalonate and ketogenesis routes may participate in regulating the cardiomyocyte cell cycle.

TL;DR: A negative correlation of serum lipids with 3-hydroxybutyric acid is found, suggesting an association between decreased lipid levels and fatty acid oxidation, in ovarian cancer patients, with clinical implications.