Paul J. van Diest

TL;DR: The authors state quite firmly that they no longer recommend the use of ISH methods, and advice is given on relevant methodological and interpretation questions such as the need for centralisation, trained staff, quality control and the handling of referral tissue samples.

TL;DR: The CONFIDENT-P trial as discussed by the authors is a SPIRIT-AI compliant single-centre, clinical trial, in a fully digital academic pathology laboratory, in which pathologists will assess whole slide images (WSI) of the standard haematoxylin-eosin (HE)-stained sections assisted by the output of a CE-IVD approved prostate cancer detection and grading algorithm.

TL;DR: In this article , the yield of routine pathological investigation of mammaplasty specimens over three decades was evaluated in search of time trends, and significant findings were defined as those that may lead to more intensive follow-up or surgical intervention.

TL;DR: In this article , it was shown that DDX3 plays a unique role in DNA damage repair (DDR) in Ewing sarcoma (EWS) cells, and that inhibition of the RNA helicase activity increases RNA:DNA hybrid structures, sequestering RAD51 in the cytoplasm, thus increasing sensitivity of EWS to radiation treatment.