P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
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Journal ArticleDOI
Alcohol based tissue fixation as an alternative for formaldehyde: influence on immunohistochemistry
Hendrik F van Essen,Marina A.M. Verdaasdonk,Sabrina M Elshof,Roel A. de Weger,Paul J. van Diest +4 more
TL;DR: Omission of pepsin pretreatment seems to be important to retain proper morphology of immunostained tissues preserved in alcohol based fixatives when switching to less toxic and non-carcinogenic alcohol-based fixatives like RCL2, no major changes in the daily routine of immunohistochemistry are anticipated.
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Whole slide images as a platform for initial diagnostics in histopathology in a medium-sized routine laboratory
TL;DR: The gradual integration of WSI into routine pathology diagnostics in a medium-sized routine pathology laboratory and the implemented adjustments to the workflow are described to encourage the wide adaptation in routine diagnostics.
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Fallopian tube intraluminal tumor spread from noninvasive precursor lesions: a novel metastatic route in early pelvic carcinogenesis.
Jonathan G. Bijron,Cornelis A. Seldenrijk,Ronald P. Zweemer,Joost G. Lange,René H.M. Verheijen,Paul J. van Diest +5 more
TL;DR: It is shown that intraluminal shedding of tumor cells in the fallopian tubes from serous carcinoma cases are common and a likely route of abdominal spread, and warrant a reconsideration of the malignant potential of STICs and indicate that intralsized shedding could be a risk factor for early intraperitoneal metastasis.
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Loss of p120‐catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling
Ron C. J. Schackmann,Sjoerd Klarenbeek,Eva J. Vlug,Suzan Stelloo,Miranda van Amersfoort,Milou Tenhagen,Tanya M. Braumuller,Jeroen F. Vermeulen,Petra van der Groep,Ton Peeters,Elsken van der Wall,Paul J. van Diest,Jos Jonkers,Patrick W. B. Derksen +13 more
TL;DR: It is shown that somatic loss of p120-catenin (p120) in a conditional mouse model of noninvasive mammary carcinoma results in formation of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes.
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Mutation profiling of key cancer genes in primary breast cancers and their distant metastases
Willemijne A. M. E. Schrijver,Pier Selenica,Ju Youn Lee,Charlotte K.Y. Ng,Kathleen A. Burke,Salvatore Piscuoglio,Samuel H. Berman,Jorge S. Reis-Filho,Britta Weigelt,Paul J. van Diest,Cathy B. Moelans +10 more
TL;DR: Somatic genetic alterations in ER-negative breast cancer metastases may be distinct from those of their primary tumors, suggesting that for treatment-decision making, genetic analyses of DNA obtained from the metastatic lesion rather than from the primary tumor should be considered.