P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
Papers
More filters
Journal ArticleDOI
No Amplifications of Hypoxia-Inducible Factor-1α Gene in Invasive Breast Cancer: A Tissue Microarray Study
Marije M. Vleugel,Reinhard Bos,Horst Buerger,Petra van der Groep,Outi R. Saramäki,Tapio Visakorpi,Elsken van der Wall,Paul J. van Diest +7 more
TL;DR: Increased protein levels of HIF‐1α are not associated with amplification of the HIF-1α gene in human breast cancer, therefore, other mechanisms than gene amplification must be responsible for Hif‐α overexpression at normoxia.
Journal ArticleDOI
Novel microtubule-interacting phenoxy pyridine and phenyl sulfanyl pyridine analogues for cancer therapy.
Ravi K. Anchoori,Madeleine S. Q. Kortenhorst,Manuel Hidalgo,Taradas Sarkar,Gurulingappa Hallur,Ruoli Bai,Paul J. van Diest,Ernest Hamel,Saeed R. Khan +8 more
TL;DR: Results show that these novel microtubule inhibitors have promising anticancer activity and can be potentially used to overcome paclitaxel resistance in the clinical setting.
Journal ArticleDOI
Immunophenotyping invasive breast cancer: paving the road for molecular imaging
Jeroen F. Vermeulen,Aram S. A. van Brussel,Petra van der Groep,Folkert H.M. Morsink,Peter Bult,Elsken van der Wall,Paul J. van Diest +6 more
TL;DR: 80% of all breast cancers express at least one of a panel of membrane markers (CD44v6, GLUT1, EGFR, HER2, and IGF1-R) that may therefore be suitable for molecular imaging strategies, and this study serves as a starting point for further development of a set of antibody-based optical tracers with a high breast cancer detection rate.
Journal ArticleDOI
Digital pathology in the time of corona.
Nikolas Stathonikos,Nadege C van Varsseveld,Aryan Vink,Marijke R. van Dijk,Tri Q. Nguyen,Wendy W J de Leng,Miangela M Lacle,Roel Goldschmeding,C. Vreuls,Paul J. van Diest +9 more
TL;DR: This paper provides an overview of the way of working during the 2020 COVID-19 crisis with emphasis on the virtues of digital pathology.
Journal ArticleDOI
Fibrotic focus and hypoxia in male breast cancer
Robert Kornegoor,Anoek H J Verschuur-Maes,Horst Buerger,Marieke C H Hogenes,Peter C. de Bruin,Joost J. Oudejans,Bernd Hinrichs,Paul J. van Diest +7 more
TL;DR: The presence of a fibrotic focus is associated with hypoxia-inducible factor-1α overexpression, and both are associated with aggressive tumor phenotype and poor survival in male breast cancer.