P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
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Journal ArticleDOI
Threshold analysis and biodistribution of fluorescently labeled bevacizumab in human breast cancer
Maximilian Koch,Johannes S. de Jong,Jürgen Glatz,Panagiotis Symvoulidis,Laetitia E. Lamberts,Arthur Adams,Mariëtte E.G. Kranendonk,Anton G.T. Terwisscha van Scheltinga,Michaela Aichler,Liesbeth Jansen,Jakob de Vries,Marjolijn N. Lub-de Hooge,Carolien P. Schröder,Annelies Jorritsma-Smit,Matthijs D. Linssen,Esther de Boer,Bert van der Vegt,Wouter B. Nagengast,Sjoerd G. Elias,Sabrina Oliveira,Arjen J. Witkamp,Willem P.Th.M. Mali,Elsken van der Wall,P. Beatriz Garcia-Allende,Paul J. van Diest,Elisabeth G.E. de Vries,Axel Walch,Gooitzen M. van Dam,Vasilis Ntziachristos +28 more
TL;DR: The development of fSTREAM is reported, a set of analytic methods designed to streamline the analysis of surgically excised breast tissues by collecting and statistically processing hybrid multiscale fluorescence, color, and histology readouts toward precision fluorescence imaging.
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Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients
Erwin Krikken,Vitaliy Khlebnikov,Moritz Zaiss,Rajni A. Jibodh,Paul J. van Diest,Peter R. Luijten,Dennis W.J. Klomp,Hanneke W. M. van Laarhoven,Jannie P. Wijnen +8 more
TL;DR: This preliminary study shows the feasibility of using APT CEST magnetic resonance imaging as a noninvasive biomarker to assess the effect of NAC in an early stage of Nac treatment of breast cancer patients.
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Real-time 3D fluoroscopy-guided large core needle biopsy of renal masses: a critical early evaluation according to the IDEAL recommendations.
Stephanie G.C. Kroeze,Merel Huisman,Helena M. Verkooijen,Paul J. van Diest,J.L.H. Ruud Bosch,Maurice A.A.J. van den Bosch +5 more
TL;DR: 3D real-time fluoroscopy cone beam CT-guided biopsy of renal masses is feasible and safe, however, these first results suggest that diagnostic accuracy may be limited in patients with renal masses <2.5 cm.
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Nanobody-targeted photodynamic therapy induces significant tumor regression of trastuzumab-resistant HER2-positive breast cancer, after a single treatment session
Marion M. Deken,Marta M. Kijanka,Irati Beltrán Hernández,Maxime D. Slooter,Henriëtte S. de Bruijn,Paul J. van Diest,Paul M.P. van Bergen en Henegouwen,Clemens Löwik,Dominic J. Robinson,Alexander L. Vahrmeijer,Sabrina Oliveira +10 more
TL;DR: In vivo, quantitative fluorescence spectroscopy showed specific accumulation of nanobody-PS conjugates in HCC1954 tumors and indicated 2 h post injection as the most suitable time point to apply light, whereas in low HER2 expressing tumors only a slight growth delay was observed.
Journal ArticleDOI
Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases
Laura S. Jiwa,Paul J. van Diest,Laurien D.C. Hoefnagel,Jelle Wesseling,Pieter Wesseling,Cathy B. Moelans +5 more
TL;DR: Claudin-4 is frequently expressed in primary breast cancers but especially in their metastases and is thereby an attractive membrane bound molecular imaging and drug target.