P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
Papers
More filters
Journal ArticleDOI
Detection of breast cancer precursor lesions by autofluorescence ductoscopy
Laurien Waaijer,Mando D. Filipe,J. M. Simons,Carmen C. van der Pol,Tjeerd de Boorder,Paul J. van Diest,Arjen J. Witkamp +6 more
TL;DR: In vivo feasibility of autofluorescence ductoscopy to detect pathologically confirmed breast cancer precursor lesions in both breast cancer patients and high-risk women that were occult under white light is demonstrated for the first time.
Journal ArticleDOI
Long-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study
Gwen M. H. E. Dackus,Natalie D. ter Hoeve,Mark Opdam,Willem Vreuls,Zsuzsanna Varga,Esther A. Koop,Stefan M. Willems,Carolien H.M. van Deurzen,Emilie J. Groen,Alicia Cordoba,Jos Bart,Antien L. Mooyaart,Jan G. van den Tweel,Vicky Zolota,Jelle Wesseling,Anna Sapino,Ewa Chmielik,Ales Ryska,Ales Ryska,Frédéric Amant,Annegien Broeks,Ron M. Kerkhoven,Nikolas Stathonikos,Mitko Veta,Adri C. Voogd,Katarzyna Jozwiak,Michael Hauptmann,Marlous Hoogstraat,Marjanka K. Schmidt,Gabe S. Sonke,Elsken van der Wall,Sabine Siesling,Paul J. van Diest,Sabine C. Linn +33 more
TL;DR: Differences in gene expression found between patients with a favourable and those with a less favourable prognosis will be used to establish a prognostic classifier, using the triple negative patients as proof of principle.
Journal ArticleDOI
Working toward consensus among professionals in the identification of classical cervical cytomorphological characteristics in whole slide images
TL;DR: In this paper, the authors used a selection of WSI from thin-layer specimens of the most common cervical infections and (pre) neoplastic lesions, and hypothesized that weekly WSI based case-meetings would help to obtain optimal acceptance of the new digital workflow in daily pathology practice.
Journal ArticleDOI
Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice
Jolien S. de Groot,Paul J. van Diest,Miranda van Amersfoort,Eva J. Vlug,Xiaojuan Pan,Natalie D. ter Hoeve,Hilde Rosing,Jos H. Beijnen,Jos H. Beijnen,Sameh A. Youssef,Alain de Bruin,Jos Jonkers,Elsken van der Wall,Patrick W. B. Derksen +13 more
TL;DR: ID cisplatin treatment only presents a safe and feasible local prevention option if systemic exposure to the chemotherapy used can be avoided, and this approach attenuated tumor onset in a mouse model of Brca1-associated breast cancer from 153 to 239 days.
Journal ArticleDOI
Role of columnar cell lesions in breast carcinogenesis: analysis of chromosome 16 copy number changes by multiplex ligation-dependent probe amplification
Mirthe de Boer,Anoek H J Verschuur-Maes,Horst Buerger,Cathy B. Moelans,Maryvonne Steenkamer,Suvi Savola,Paul J. van Diest +6 more
TL;DR: Columnar cell lesions (with and without atypia) often harbour whole-arm losses of 16q, which underlines their role as precursors in low-grade breast carcinogenesis, in contrast with usual ductal hyperplasia and blunt duct adenosis.