Paul J. van Diest

TL;DR: An accurate tissue processing and registration method was presented, which enables the validation of MR based tumor delineations with pathology, which yielded a tumor coverage of 85-100% in all patients.

TL;DR: It is shown that true polysomy of chromosome 17, either of the whole chromosome or of the short or the long arm, is very rare in invasive breast cancer, and correction with CEP17 probes may provide misleading HER2 gene status assessment results.

TL;DR: In this article, the setup of the digital archiving solution is described and the technical challenges the team had to overcome are discussed and some statistics are provided to give insight in the performance of the archive.

TL;DR: Analyzing 20 breast cancer-related genes in 104 invasive breast cancers with the use of multiplex ligation-dependent probe amplification allowed to simultaneously assess copy numbers of 20 important breast cancer genes, providing an overview of the most frequent (co)amplifications as well as interesting phenotypic correlations, and thereby data on the potential importance of these genes in breast cancer.

TL;DR: Not performing axillary treatment in patients with SLN micrometastases is associated with an increased 5-year regional recurrence rate, and favorable primary tumor characteristics and unfavorable tumor characteristics were significantly associated with recurrence.