P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
Papers
More filters
Journal ArticleDOI
Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer
Marise R. Heerman van Voss,Farhad Vesuna,Guus M. Bol,Jan Meeldijk,Ana Raman,G. Johan A. Offerhaus,Horst Buerger,Arvind H. Patel,Elsken van der Wall,Paul J. van Diest,Venu Raman +10 more
TL;DR: It is concluded that nuclear DDX3 is partially CRM1-mediated and predicts worse survival in colorectal and breast cancer patients, putting it forward as a target for therapeutic intervention withDDX3 inhibitors under development in these cancer types.
Journal ArticleDOI
SlideToolkit: An Assistive Toolset for the Histological Quantification of Whole Slide Images
Bastiaan G. L. Nelissen,Joost A. van Herwaarden,Frans L. Moll,Paul J. van Diest,Gerard Pasterkamp +4 more
TL;DR: The slideToolkit is demonstrated by a repeated measurement of 303 digital slides containing CD3 stained (DAB) abdominal aortic aneurysm tissue from a tissue biobank, which showed an intraclass correlation of 0.99.
Journal ArticleDOI
Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast
Aram S. A. van Brussel,Arthur Adams,Jeroen F. Vermeulen,Sabrina Oliveira,Elsken van der Wall,Willem P.Th.M. Mali,Paul J. van Diest,Paul M.P. van Bergen en Henegouwen +7 more
TL;DR: Molecular fluorescence imaging with MabCAIX-IRDye800CW can be successfully used to detect hypoxic DCIS before and during surgery to facilitate radical resection and introduce the concept of molecular fluorescence pathology.
Journal ArticleDOI
Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer.
Karijn P M Suijkerbuijk,Elsken van der Wall,Helen Meijrink,Xiaojuan Pan,Inne H.M. Borel Rinkes,Margreet G. E. M. Ausems,Paul J. van Diest +6 more
TL;DR: Oxytocin-assisted nipple aspiration is performed in 90 women at increased risk for breast cancer based on family history or genetic test results and/or previous breast cancer, suggesting that a new tool for biomarker detection in oxytocin -assisted nipple fluid of women at high risk for Breast cancer is at hand.
Journal ArticleDOI
Intratumoral heterogeneity of Ki67 expression in early breast cancers exceeds variability between individual tumours.
TL;DR: The aim was to study the intratumoral heterogeneity of Ki67 expression in early breast cancers and its association with clinicopathological features, such as oestrogen receptor (ER) status, grade and histological subtype.