P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
Papers
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Journal ArticleDOI
Digital pathology: current status and future perspectives.
TL;DR: Al‐Janabi S, Huisman A & Van Diest P J ’(2012) Histopathology 61, 1–9
Journal ArticleDOI
Prevalence of HPV in cytomorphologically normal cervical smears, as determined by the polymerase chain reaction, is age-dependent
Peter W. J. Melkert,Adriaan J. C. van den Brule,Elle K.J. Risse,Paul J. van Diest,Chris J.L.M. Meijer,Jan M. M. Walboomers,Theo J.M. Helmerhorst,Ellen H. Hopman,O. P. Bleker,M.E.I. Schipper +9 more
TL;DR: The results indicate that genital HPV infections are age‐dependent and suggest that HPV infections at young age can be transient, and the implications of these findings in the context of cervical cancer screening are discussed.
Journal ArticleDOI
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
Yelena Mironchik,Paul T. Winnard,Farhad Vesuna,Yoshinori Kato,Flonne Wildes,Arvind P. Pathak,Scott Kominsky,Dmitri Artemov,Zaver M. Bhujwalla,Paul J. van Diest,Horst Bürger,Carlotta A. Glackin,Venu Raman +12 more
TL;DR: Stable overexpression of Twist in a breast cancer cell line, MCF-7, altered its morphology to a fibroblastic-like phenotype, which exhibited protein markers representative of a mesenchymal transformation that is pivotal for the transformation into an aggressive breast cancer phenotype.
Journal Article
Impact of lymphoscintigraphy on sentinel node identification with technetium-99m-colloidal albumin in breast cancer.
Rik Pijpers,Sybren L. Meijer,Otto S. Hoekstra,Gerard J. Collet,Emile F.I. Comans,Rob P.A. Boom,Paul J. van Diest,Gerrit J.J. Teule +7 more
TL;DR: The selective targeting and prolonged intranodal retention of 99mTc-colloidal albumin allows successful sentinel node identification in most (92%) patients.
Journal ArticleDOI
Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity
Evelyne Beerling,Danielle Seinstra,Elzo de Wit,Elzo de Wit,Lennart Kester,Daphne L. van der Velden,Carrie Maynard,Ronny Schäfer,Paul J. van Diest,Emile E. Voest,Alexander van Oudenaarden,Nienke Vrisekoop,Jacco van Rheenen +12 more
TL;DR: It is found that epithelial-mesenchymal plasticity supports migration but additionally eliminates stemness-enhanced metastatic outgrowth differences, and renders any EMT-induced stemness differences irrelevant for metastaticOutgrowth.