P
Paul J. van Diest
Researcher at Utrecht University
Publications - 514
Citations - 22750
Paul J. van Diest is an academic researcher from Utrecht University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 70, co-authored 459 publications receiving 18892 citations. Previous affiliations of Paul J. van Diest include University Medical Center Utrecht & VU University Medical Center.
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Journal ArticleDOI
Primary Colorectal Cancers and Their Subsequent Hepatic Metastases Are Genetically Different: Implications for Selection of Patients for Targeted Treatment
Joost S.P. Vermaat,Isaac J. Nijman,Marco J. Koudijs,Frank L. Gerritse,Stefan Scherer,Michal Mokry,Wijnand Roessingh,Nico Lansu,Ewart de Bruijn,Richard van Hillegersberg,Paul J. van Diest,Edwin Cuppen,Emile E. Voest +12 more
TL;DR: The study indicates that the genetic characteristics of the hepatic metastases are different from those of the primary CRC tumor, and the choice of treatment in studies investigating targeted therapies should ideally be based on the genetic properties of the metastasis rather than on those ofThe primary tumor.
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Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer†
TL;DR: Promoter hypermethylation of PAX6, BRCA2, PAX5, WT1, CDH13 and MSH6 seems to be a frequent early event in breast cancer and methylation levels of GSTP1 (and CDKN2A, although still low) seem to increase with increasing DCIS grade.
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Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model
Jarmila D. W. van der Bilt,Onno Kranenburg,Maarten W. Nijkamp,Niels Smakman,Liesbeth M. Veenendaal,Elisabeth A. te Velde,Emile E. Voest,Paul J. van Diest,Inne H.M. Borel Rinkes +8 more
TL;DR: I/R is a strong stimulus of recurrent intrahepatic tumor growth and measures to prevent I/R‐induced late tissue necrosis cross‐protect against this phenomenon are outlined.
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Hypoxic regulation of metastasis via hypoxia-inducible factors.
TL;DR: It is hypothesize that polyclonal tumor selection by hypoxia enhances metastatic capacity by transcriptional control of key regulators of metastasis, and may provide a prognostic indicator in clinical decision-making.