Pepijn Schellen

TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.

TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.

TL;DR: Platelets are a valuable source for the non-invasive detection of EML4-ALK rearrangements and may prove useful for predicting and monitoring outcome to crizotinib, thereby improving clinical decisions based on radiographic imaging alone.

TL;DR: Subventricular tumor spread is shown in the majority of patients, typically later in the course of their disease, as future therapies evolve to control local disease, strategies including extended or whole brain irradiation may become crucial as therapies improve and patients survive longer in the natural history of their cancer.

TL;DR: Results show that inhibition of WEE1 kinase in conjunction with radiotherapy holds potential as a therapeutic approach for the treatment of DIPG.