P
Pepijn Schellen
Researcher at VU University Medical Center
Publications - 13
Citations - 1388
Pepijn Schellen is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Cancer & Crizotinib. The author has an hindex of 10, co-authored 12 publications receiving 1015 citations.
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Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer.
R. Jonas A. Nilsson,Niki Karachaliou,Jordi Berenguer,Ana Giménez-Capitán,Pepijn Schellen,Cristina Teixidó,Jihane Tannous,Justine L. Kuiper,Esther Drees,Magda Grabowska,Marte van Keulen,Daniëlle A.M. Heideman,Erik Thunnissen,Anne-Marie C. Dingemans,Santiago Viteri,Bakhos A. Tannous,Ana Drozdowskyj,Rafael Rosell,Egbert F. Smit,Thomas Wurdinger +19 more
TL;DR: Platelets are a valuable source for the non-invasive detection of EML4-ALK rearrangements and may prove useful for predicting and monitoring outcome to crizotinib, thereby improving clinical decisions based on radiographic imaging alone.
Journal ArticleDOI
Subventricular spread of diffuse intrinsic pontine glioma.
Viola Caretti,Marianna Bugiani,Morgan E. Freret,Pepijn Schellen,Marc H. A. Jansen,Dannis G. van Vuurden,Gertjan J.L. Kaspers,Paul G. Fisher,Esther Hulleman,Pieter Wesseling,Pieter Wesseling,Hannes Vogel,Michelle Monje +12 more
TL;DR: Subventricular tumor spread is shown in the majority of patients, typically later in the course of their disease, as future therapies evolve to control local disease, strategies including extended or whole brain irradiation may become crucial as therapies improve and patients survive longer in the natural history of their cancer.
Journal ArticleDOI
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas
Viola Caretti,Lotte Hiddingh,Tonny Lagerweij,Pepijn Schellen,Phil W. Koken,Esther Hulleman,Dannis G. van Vuurden,W. Peter Vandertop,Gertjan J.L. Kaspers,D. P. Noske,Thomas Wurdinger +10 more
TL;DR: Results show that inhibition of WEE1 kinase in conjunction with radiotherapy holds potential as a therapeutic approach for the treatment of DIPG.