Puyi Qian

TL;DR: Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene.

TL;DR: It is demonstrated that changes in the amount of mtDNA and telomere length are consequences of stress and entering a depressed state and have important implications for understanding how stress causes the disease.

TL;DR: Insight is offered into the potential mechanisms of cfRNAs to explain COVID-19 pathogenesis and several pneumonia-related microorganisms were detected in the plasma of COIDs, raising the possibility of simultaneously monitoring immune response regulation and microbial communities using cfRNA analysis.

TL;DR: The findings suggest that participants may obtain benefit from PGx profiling already in early childhood, and compared with routine NBS, WGS pro-duced fewer false positive results and identified more actionable pathogenic or likely pathogenic variants in the selective 246 genes.

TL;DR: In this article , the authors performed whole-genome sequencing of Parascaris univalens from different Equus hosts (horses, zebras and donkeys) and performed phylogenetic and selection analyses to study the divergence and adaptability of P. univalentens.