Randall T. Moon

TL;DR: This work has shown that WNTs and their downstream effectors regulate various processes that are important for cancer progression, including tumour initiation, tumour growth, cell senescence, cell death, differentiation and metastasis, and improved drug-discovery platforms and new technologies have facilitated the discovery of agents that can alter WNT signalling in preclinical models.

TL;DR: WNT signalling has been studied primarily in developing embryos, but WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer.

TL;DR: Recent developments in both the functions and mechanisms of noncanonical Wnt signaling are reviewed, and some challenges and difficulties the field faces are outlined.

TL;DR: It is demonstrated thatosphorylation of beta-catenin in vivo requires an in vitro amino-terminal Xgsk-3 phosphorylation site, which is conserved in the Drosophila protein armadillo, which provides a basis for understanding the interaction between XgSk-3 and beta-catsin in the establishment of the dorsal-ventral axis in early Xenopus embryos.

TL;DR: Intriguingly, the transmembrane receptor Tyr kinases Ror2 and Ryk, as well as Frizzled receptors that act independently of LRP5 or LRP6, function as receptors for Wnt and activate β-catenin-independent pathways, which leads to changes in cell movement and polarity and to the antagonism of the β- catenin pathway.