R
Regan Scott
Researcher at University of Pittsburgh
Publications - 7
Citations - 1924
Regan Scott is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 6, co-authored 7 publications receiving 1820 citations.
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Journal ArticleDOI
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Carl A. Anderson,Gabrielle Boucher,Charlie W. Lees,Andre Franke,Mauro D'Amato,Kent D. Taylor,James Lee,Philippe Goyette,Marcin Imielinski,Anna Latiano,Caroline Lagacé,Regan Scott,Leila Amininejad,Suzannah Bumpstead,Leonard Baidoo,Robert N. Baldassano,Murray L. Barclay,Theodore M. Bayless,Stephan Brand,Carsten Büning,Jean-Frederic Colombel,Lee A. Denson,Martine De Vos,Marla Dubinsky,Cathryn Edwards,David Ellinghaus,Rudolf S N Fehrmann,James A B Floyd,Timothy H. Florin,Denis Franchimont,Lude Franke,Michel Georges,Jürgen Glas,Nicole L. Glazer,Stephen L. Guthery,Talin Haritunians,Nicholas K. Hayward,Jean-Pierre Hugot,Gilles Jobin,Debby Laukens,Ian C. Lawrance,Marc Lémann,Arie Levine,Cécile Libioulle,Edouard Louis,Dermot P.B. McGovern,Monica Milla,Grant W. Montgomery,Katherine I. Morley,Craig Mowat,Aylwin Ng,William G. Newman,Roel A. Ophoff,Laura Papi,Orazio Palmieri,Laurent Peyrin-Biroulet,Julián Panés,Anne M. Phillips,Natalie J. Prescott,Deborah D. Proctor,Rebecca L. Roberts,Richard K Russell,Paul Rutgeerts,Jeremy D. Sanderson,Miquel Sans,Philip Schumm,Frank Seibold,Yashoda Sharma,Lisa A. Simms,Mark Seielstad,Mark Seielstad,A. Hillary Steinhart,Stephan R. Targan,Leonard H. van den Berg,Morten H. Vatn,Hein W. Verspaget,Thomas D. Walters,Cisca Wijmenga,David C. Wilson,Harm-Jan Westra,Ramnik J. Xavier,Zhen Zhen Zhao,Cyriel Y. Ponsioen,Vibeke Andersen,Leif Törkvist,Maria Gazouli,Nicholas P. Anagnou,Tom H. Karlsen,Limas Kupčinskas,Jurgita Sventoraityte,John C. Mansfield,Subra Kugathasan,Mark S. Silverberg,Jonas Halfvarson,Jerome I. Rotter,Christopher G. Mathew,Anne M. Griffiths,Richard B. Gearry,Tariq Ahmad,Steven R. Brant,Mathias Chamaillard,Jack Satsangi,Judy H. Cho,Stefan Schreiber,Mark J. Daly,Jeffrey C. Barrett,Miles Parkes,Vito Annese,Hakon Hakonarson,Graham L. Radford-Smith,Richard H. Duerr,Severine Vermeire,Rinse K. Weersma,John D. Rioux +113 more
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Journal ArticleDOI
Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
Mark S. Silverberg,Judy H. Cho,John D. Rioux,Dermot P.B. McGovern,Jing Wu,Vito Annese,Jean Paul Achkar,Philippe Goyette,Regan Scott,Wei Xu,M. Michael Barmada,Lambertus Klei,Mark J. Daly,Clara Abraham,Theodore M. Bayless,Fabrizio Bossa,Anne M. Griffiths,Andrew Ippoliti,Raymond G. Lahaie,Anna Latiano,Pierre Paré,Deborah D. Proctor,Miguel Regueiro,A. Hillary Steinhart,Stephan R. Targan,L. Philip Schumm,Emily O. Kistner,Annette Lee,Peter K. Gregersen,Jerome I. Rotter,Steven R. Brant,Kent D. Taylor,Kathryn Roeder,Richard H. Duerr +33 more
TL;DR: Combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 and at the IL23R locus on chromosome 1p31, and in an analysis that controlled for gender and population structure.
Journal ArticleDOI
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
Eleonora A. M. Festen,Philippe Goyette,Regan Scott,Vito Annese,Alexandra Zhernakova,Jing Lian,C. Lefebvre,Steven R. Brant,Judy H. Cho,Mark S. Silverberg,Kent D. Taylor,Dirk J. de Jong,Pieter C. F. Stokkers,Dermot P. McGovern,Orazio Palmieri,Jean-Paul Achkar,Ramnik J. Xavier,Mark J. Daly,Richard H. Duerr,Cisca Wijmenga,Rinse K. Weersma,John D. Rioux +21 more
TL;DR: A strong association for the IL2/IL21 locus with UC was found, which confirms it as a general susceptibility locus for inflammatory disease.
Journal ArticleDOI
Erratum: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study(Nature Genetics (2009) 41 (216220))
Mark S. Silverberg,Judy H. Cho,John D. Rioux,Dermot P.B. McGovern,Jing Wu,Vito Annese,Jean Paul Achkar,Philippe Goyette,Regan Scott,Wei Xu,M. Michael Barmada,Lambertus Klei,Mark J. Daly,Clara Abraham,Theodore M. Bayless,Fabrizio Bossa,Anne M. Griffiths,Andrew Ippoliti,Raymond G. Lahaie,Anna Latiano,Pierre Paré,Deborah D. Proctor,Miguel Regueiro,A. Hillary Steinhart,Stephan R. Targan,L. Philip Schumm,Emily O. Kistner,Annette Lee,Peter K. Gregersen,Jerome I. Rotter,Steven R. Brant,Kent D. Taylor,Kathryn Roeder,Richard H. Duerr +33 more
TL;DR: In the first paragraph of the second column on the third page, rs11209026 A allele was incorrectly listed as rs111209025 A allele, which has been corrected in the HTML and PDF versions of the article.
Journal ArticleDOI
Amino acid position 11 of HLA-DRβ1 is a major determinant of chromosome 6p association with ulcerative colitis.
Jean-Paul Achkar,Jean-Paul Achkar,Lambertus Klei,P. I W De Bakker,P. I W De Bakker,P. I W De Bakker,Gaia Bellone,N. Rebert,Regan Scott,Ying Lu,Miguel Regueiro,Aaron Brzezinski,Kamboh Mi,Claudio Fiocchi,Claudio Fiocchi,Bernie Devlin,Massimo Trucco,Steven Ringquist,Kathyrn Roeder,Richard H. Duerr +19 more
TL;DR: Variation at HLA-DRβ1, amino acid 11 in the P6 pocket of the Hla-DR complex antigen binding cleft is a major determinant of chromosome 6p association with UC.