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Ren-Di Jiang
Researcher at Chinese Academy of Sciences
Publications - 25
Citations - 4008
Ren-Di Jiang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 16 publications receiving 2404 citations. Previous affiliations of Ren-Di Jiang include ShanghaiTech University.
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Journal ArticleDOI
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
ComponentDOI
Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xingyu Du,Ya-Xi Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xingzhou Li,L. Z. Zhang,Chao Peng,Yinkai Duan,Jing Yu,Linfang Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xuejie Yang,Tian You,Liu X,Fang Bai,He-Qun Liu,Luke W. Guddat,Wenbo Xu,Wenbo Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Haiying Jiang,Haiying Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +33 more
TL;DR: The results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.
Journal ArticleDOI
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.
Chao Shan,Yanfeng Yao,Xing-Lou Yang,Yiwu Zhou,Ge Gao,Yun Peng,Lian Yang,Xue Hu,Jin Xiong,Ren-Di Jiang,Huajun Zhang,Xiaoxiao Gao,Cheng Peng,Juan Min,Ying Chen,Hao-Rui Si,Jia Wu,Peng Zhou,Yan-Yi Wang,Hongping Wei,Wei Pang,Zheng-Fei Hu,Longbao Lv,Yong-Tang Zheng,Zhengli Shi,Zhiming Yuan +25 more
TL;DR: It is demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2, and the non-human primate model that is established here provides a valuable platform to study Sars-Co V-2 pathogenesis and to evaluate candidate vaccines and therapeutics.
Journal ArticleDOI
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques.
Liqiang Feng,Liqiang Feng,Qian Wang,Qian Wang,Chao Shan,Chenchen Yang,Ying Feng,Jia Wu,Liu Xiaolin,Yiwu Zhou,Ren-Di Jiang,Peiyu Hu,Xinglong Liu,Fan Zhang,Pingchao Li,Xuefeng Niu,Yichu Liu,Xuehua Zheng,Jia Luo,Jing Sun,Yingying Gu,Bo Liu,Yongcun Xu,Chufang Li,Weiqi Pan,Jincun Zhao,Changwen Ke,Xinwen Chen,Tao Xu,Nanshan Zhong,Guan Suhua,Zhiming Yuan,Ling Chen,Ling Chen +33 more
TL;DR: A replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike is generated, protection from infection in non-human primates is shown, and the immune response after intramuscular and intranasal vaccination is analyzed.
Journal ArticleDOI
Characterization of a filovirus (Měnglà virus) from Rousettus bats in China
Xing-Lou Yang,Xing-Lou Yang,Chee Wah Tan,Danielle E. Anderson,Ren-Di Jiang,Bei Li,Wei Zhang,Yan Zhu,Xiao Fang Lim,Peng Zhou,Xiang-Ling Liu,Wuxiang Guan,Libiao Zhang,Shi-Yue Li,Yun-Zhi Zhang,Lin-Fa Wang,Zhengli Shi +16 more
TL;DR: The characterization of a phylogenetically distinct bat filovirus, named Měnglà virus (MLAV), whose genome shares 32–54% nucleotide sequence identity with known filoviruses, indicates a broad species cell tropism with a high risk of interspecies spillover transmission.