R
Robert W. Myers
Researcher at Merck & Co.
Publications - 63
Citations - 7661
Robert W. Myers is an academic researcher from Merck & Co.. The author has contributed to research in topics: Histone deacetylase & Apicidin. The author has an hindex of 24, co-authored 61 publications receiving 7011 citations. Previous affiliations of Robert W. Myers include Johns Hopkins University & Southern Illinois University Carbondale.
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Journal ArticleDOI
Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
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Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase
Sandra J. Darkin-Rattray,Anne Gurnett,Robert W. Myers,Paula M. Dulski,Tami Crumley,John J. Allocco,Christine Lange Cannova,Peter T. Meinke,Steven L. Colletti,Maria A. Bednarek,Sheo B. Singh,Michael A. Goetz,Anne W. Dombrowski,Jon D. Polishook,Dennis M. Schmatz +14 more
TL;DR: A novel fungal metabolite, apicidin, that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been identified and is also orally and parenterally active in vivo against Plasmodium berghei malaria in mice.
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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Robert W. Myers,Hong-Ping Guan,Juliann Ehrhart,Aleksandr Petrov,Srinivasa Prahalada,Effie Tozzo,Xiaodong Yang,Marc M. Kurtz,Maria E. Trujillo,Dinko Gonzalez Trotter,Danqing Feng,Shiyao Xu,George J. Eiermann,Marie A. Holahan,Daniel Rubins,Stacey Conarello,Xiaoda Niu,Sandra C. Souza,Corin O. Miller,Jinqi Liu,Ku Lu,Wen Feng,Ying Li,Ronald E. Painter,James A. Milligan,Huaibing He,Franklin Liu,Aimie Ogawa,Douglas Wisniewski,Rory J. Rohm,Liyang Wang,Michelle Bunzel,Ying Qian,Wei Zhu,Hongwu Wang,Bindu Bennet,Lisa LaFranco Scheuch,Guillermo Fernandez,Cai Li,Michael Klimas,Gaochao Zhou,Margaret van Heek,Tesfaye Biftu,Ann E. Weber,David E. Kelley,Nancy A. Thornberry,Mark D. Erion,Daniel M. Kemp,Iyassu K. Sebhat +48 more
TL;DR: MK-8722 is developed, a potent, direct, allosteric activator of all 12 mammalian AMPK complexes that induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia in rodents and rhesus monkeys.
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The synthesis of 4-methylumbelliferyl α-ketoside of N-acetylneuraminic acid and its use in a fluorometric assay for neuraminidase☆
Robert W. Myers,Reiko T. Lee,Yuan C. Lee,George H. Thomas,Linda W. Reynolds,Yoshihiro Uchida +5 more
TL;DR: 4-Methylumbelliferyl α-ketoside of N- acetylneuraminic acid was synthesized by reacting the sodium salt of 4-methylumbelliferone with the 2-chloro-2-deoxy derivative of peracetylated methyl N-acetylNEuraminate, followed by preparative silica gel chromatography, deblocking, and purification by gel filtration on Sephadex G-25.
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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
Herbert G. Bull,Margarita Garcia-Calvo,Stefan Andersson,Walter F. Baginsky,H. Karen Chan,Dina E. Ellsworth,Randall R. Miller,Ralph A. Stearns,Raman K. Bakshi,Gary H. Rasmusson,Richard L. Tolman,Robert W. Myers,and John W. Kozarich,Georgianna Harris +13 more
TL;DR: The intermediate NADP−dihydrofinasteride adduct can be recovered intact by denaturation of the enzyme−inhibitor complex and has been purified.