R
Ron Diskin
Researcher at Weizmann Institute of Science
Publications - 72
Citations - 5408
Ron Diskin is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Antibody & Lassa virus. The author has an hindex of 27, co-authored 65 publications receiving 4584 citations. Previous affiliations of Ron Diskin include Howard Hughes Medical Institute & California Institute of Technology.
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Journal ArticleDOI
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Johannes F. Scheid,Hugo Mouquet,Beatrix Ueberheide,Ron Diskin,Florian Klein,Thiago Y. Oliveira,John Pietzsch,John Pietzsch,David Fenyö,Alexander Abadir,Klara Velinzon,Arlene Hurley,Sunnie Myung,Farid Boulad,Pascal Poignard,Pascal Poignard,Dennis R. Burton,Dennis R. Burton,Florencia Pereyra,Florencia Pereyra,David D. Ho,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Michael S. Seaman,Pamela J. Bjorkman,Pamela J. Bjorkman,Brian T. Chait,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Anti-HIV broadly neutralizing antibodies with similar specificities and modes of binding were found in multiple HIV-infected individuals, and cloned 576 new HIV antibodies from four unrelated individuals to determine whether they are part of a larger group of related molecules.
Journal ArticleDOI
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein,Ariel Halper-Stromberg,Joshua A. Horwitz,Henning Gruell,Henning Gruell,Johannes F. Scheid,Johannes F. Scheid,Stylianos Bournazos,Hugo Mouquet,Linda Spatz,Linda Spatz,Ron Diskin,Alexander Abadir,Trinity Zang,Marcus Dorner,Eva Billerbeck,Rachael N. Labitt,Christian Gaebler,Christian Gaebler,Paola Marcovecchio,Reha Baris Incesu,Thomas Eisenreich,Paul D. Bieniasz,Paul D. Bieniasz,Michael S. Seaman,Pamela J. Bjorkman,Jeffrey V. Ravetch,Alexander Ploss,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.
Journal ArticleDOI
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
Florian Klein,Ron Diskin,Ron Diskin,Johannes F. Scheid,Johannes F. Scheid,Christian Gaebler,Christian Gaebler,Hugo Mouquet,Ivelin S. Georgiev,Marie Pancera,Tongqing Zhou,Reha-Baris Incesu,Brooks Zhongzheng Fu,Priyanthi N. P. Gnanapragasam,Thiago Y. Oliveira,Thiago Y. Oliveira,Michael S. Seaman,Peter D. Kwong,Pamela J. Bjorkman,Michel C. Nussenzweig,Michel C. Nussenzweig +20 more
TL;DR: Structural and functional analyses reveal that somatic mutations in FWR residues enhance breadth and potency by providing increased flexibility and/or direct antigen contact in bNAbs, and FWRs play an essential role beyond scaffolding the CDR loops.
Journal ArticleDOI
Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design
Ron Diskin,Johannes F. Scheid,Johannes F. Scheid,Paola Marcovecchio,Anthony P. West,Florian Klein,Han Gao,Priyanthi N. P. Gnanapragasam,Alexander Abadir,Michael S. Seaman,Michel C. Nussenzweig,Michel C. Nussenzweig,Pamela J. Bjorkman +12 more
TL;DR: Structural analysis of an HIV antibody reveals residues important for neutralization breadth and potency, which indicate that gp120 inner domain and bridging sheet residues should be included in immunogens to elicit CD4bs antibodies.
Journal ArticleDOI
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients.
Christoph Kreer,Matthias Zehner,Timm Weber,Meryem S. Ercanoglu,Lutz Gieselmann,Cornelius Rohde,Sandro Halwe,M. Korenkov,Philipp Schommers,Kanika Vanshylla,Veronica Di Cristanziano,Hanna Janicki,Reinhild Brinker,Artem Ashurov,Verena Krähling,Alexandra Kupke,Hadas Cohen-Dvashi,Manuel Koch,Jan Mathis Eckert,Simone Lederer,Nico Pfeifer,Timo Wolf,Maria J G T Vehreschild,Clemens M. Wendtner,Ron Diskin,Henning Gruell,Stephan Becker,Florian Klein +27 more
TL;DR: It is demonstrated that SARS-CoV-2-neutralizing antibodies are readily generated from a diverse pool of precursors, fostering hope for rapid induction of a protective immune response upon vaccination.