Rong Jiang

TL;DR: A large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques and thrombus formation as mentioned in this paper.

TL;DR: Analysis of related phenotypes identified gene-by-stress interaction effects for waist circumference, body mass index (BMI), fasting glucose, type II diabetes status, and common carotid intimal–medial thickness (CCIMT), supporting a proposed model of gene- by- stress interaction that connects cardiovascular disease (CVD) risk factor endophenotypes such as central obesity and increased blood glucose or diabetes to CVD itself.

TL;DR: The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val 66Met in the modulation of stress reactivity and subsequent depression prevalence.

TL;DR: Race and sex play a role in how potential mediators are involved with the SES-CRP relationship, such that BMI and smoking were mediators in white men, whereas BMI was the sole mediator in white women.

TL;DR: The Val66Met genotype was associated with greater severity of CAD and incidence of CVD‐related clinical events in a patient sample, and intervention studies in clinical groups with the Val/Val genotype could be undertaken to prevent disease and improve prognosis.