S
Scott M. Grundy
Researcher at University of Texas Southwestern Medical Center
Publications - 849
Citations - 246629
Scott M. Grundy is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 187, co-authored 841 publications receiving 231821 citations. Previous affiliations of Scott M. Grundy include University of California, San Francisco & University of California, Davis.
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Influence of Combined Therapy with Mevinolin and Interruption of Bile-Acid Reabsorption on Low Density Lipoproteins in Heterozygous Familial Hypercholesterolemia
TL;DR: Drug therapy reduced cholesterol levels in patients with heterozygous familial hypercholesterolemia by an average of 52%; this response was due to a 40% increase in fractional catabolic rate of apo-LDL and a 26% decrease in its production rate.
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Studies of LDL oxidation following α-, γ-, or δ-tocotrienyl acetate supplementation of hypercholesterolemic humans
Dawn O’Byrne,Scott M. Grundy,Lester Packer,Sridevi Devaraj,K. Baldenius,P. P. Hoppe,K. Kraemer,Ishwarlal Jialal,Maret G. Traber +8 more
TL;DR: It is demonstrated that tocotrienyl acetate supplements are hydrolyzed, absorbed, and detectable in human plasma, and α-T3 may be potent in decreasing LDL oxidizability.
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Effects of fats high In stearic acid on lipid and lipoprotein concentrations in men
Margo A. Denke,Scott M. Grundy +1 more
TL;DR: The effects of beef tallow and cocoa butter, two fats with a high stearic acid content, on serum lipid and lipoprotein concentrations were compared with the effects of butter fat and olive oil in 10 middle-aged men.
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Relationship of periodic mental stress to serum lipoprotein and cholesterol levels.
Scott M. Grundy,A. C. Griffin +1 more
TL;DR: Blood samples obtained from medical students during an initial period of moderate stress were compared with samples obtained during more stressful examination periods with respect to serum lipoprotein and total serum cholesterol levels to suggest the factor that relates stress to atherosclerosis and coronary artery disease.
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Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B‐containing lipoproteins
TL;DR: Pravastatin seemingly reduced input rates for all apo B‐containing lipoproteins, consistent with previous studies, this response was most likely the result of enhanced removal of nascent lipoproteinins by increased activity of LDL receptors, although decreased synthesis of apO B in the liver is a possible second action.