S
Scott M. Grundy
Researcher at University of Texas Southwestern Medical Center
Publications - 849
Citations - 246629
Scott M. Grundy is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 187, co-authored 841 publications receiving 231821 citations. Previous affiliations of Scott M. Grundy include University of California, San Francisco & University of California, Davis.
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Journal ArticleDOI
Long-term changes in cholesterol biosynthesis and the effect of plasmapheresis therapy in a hypercholesterolemia homozygote
Richard A. Levy,Richard A. Levy,Richard E. Ostlund,Richard E. Ostlund,Anne C. Goldberg,Anne C. Goldberg,Scott M. Grundy,Scott M. Grundy +7 more
TL;DR: Chronic plasmapheresis therapy every two weeks for 3.4 years reduced plasma low-density lipoprotein cholesterol 54% but had little effect on the rate of cholesterol biosynthesis, and over the decade of study, neutral steroid excretion/kg declined 61% whereas bile acid excretion /kg was unchanged.
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Biliary lipids, gallstones and treatment of hyperlipidaemia.
TL;DR: The administration of chenodeoxycholic acid (CDCA) during caloric restriction in obese subjects will prevent formation of supersaturated bile and thus should protect against gallstone formation.
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Utility of metabolic syndrome as a risk enhancing factor in decision of statin use.
TL;DR: In this paper, the prevalence of metabolic syndrome without diabetes (MetS+) and of diabetes (DM+) were determined for 10-year risk categories estimated to be low ( Results 90.4% of the population was free of ASCVD).
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Lipid transport and lipoprotein interconversions.
TL;DR: Results indicate that a relatively small number of ether-modified residues are obtained from the entire lipoprotein spectrum of all species studied, and it is suggested that these moieties may be closely related to actual lipid-transporting components of the lipop protein system.