S
Scott M. Grundy
Researcher at University of Texas Southwestern Medical Center
Publications - 849
Citations - 246629
Scott M. Grundy is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 187, co-authored 841 publications receiving 231821 citations. Previous affiliations of Scott M. Grundy include University of California, San Francisco & University of California, Davis.
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Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: evidence for a very rapid turnover of VLDL and preferential removal of B-48- relative to B-100-containing lipoproteins.
TL;DR: This procedure provides for quantification of secretory rates of these apo proteins in vivo, and may be useful for studying the effects of genetic manipulation on the simultaneous secretion of apoB-48- and apOB-100-containing VLDL, afforded by the panoply of transgenic mouse models now available for study, as well as for effects of diet and drug therapy.
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George Lyman Duff Memorial Lecture. Multifactorial etiology of hypercholesterolemia. Implications for prevention of coronary heart disease.
TL;DR: With the exception of heterozygous FH, most cases of severe hypercholesterolemia appear to be the result of the coexistence of at least two defects in LDL metabolism, and as a rule, they can be treated successfully only by using cholesterol-lowering drugs in combination.
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Body Fat Distribution and Incident Cardiovascular Disease in Obese Adults
Ian J. Neeland,Aslan T. Turer,Colby Ayers,Jarett D. Berry,Anand Rohatgi,Sandeep R Das,Amit Khera,Gloria Lena Vega,Darren K. McGuire,Scott M. Grundy,James A. de Lemos +10 more
TL;DR: In this paper, the authors investigated the associations of novel imaging markers of adiposity, including visceral adipose tissue (VAT) and abdominal subcutaneous adiposes tissue (SAT), with the risk for cardiovascular disease (CVD) events in a multiethnic cohort of obese adults.
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Role of low-density lipoproteins in atherogenesis and development of coronary heart disease.
TL;DR: There is a strong association between increased blood concentrations of low-density lipoprotein (LDL) and severity of coronary atherosclerosis, and current concepts of LDL metabolism are extensively reviewed.