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Candelaria Vergara
Researcher at Johns Hopkins University
Publications - 36
Citations - 1160
Candelaria Vergara is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 13, co-authored 28 publications receiving 908 citations. Previous affiliations of Candelaria Vergara include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Assembly of a pan-genome from deep sequencing of 910 humans of African descent
Rachel M. Sherman,Juliet Forman,Juliet Forman,Valentin Antonescu,Daniela Puiu,Michelle Daya,Nicholas Rafaels,Meher Preethi Boorgula,Sameer Chavan,Candelaria Vergara,Victor E. Ortega,Albert M. Levin,Celeste Eng,Maria Yazdanbakhsh,James G. Wilson,Javier Marrugo,Leslie A. Lange,L. Keoki Williams,Harold Watson,Lorraine B. Ware,Christopher O. Olopade,Olufunmilayo I. Olopade,Ricardo Riccio Oliveira,Carole Ober,Dan L. Nicolae,Deborah A. Meyers,Alvaro Mayorga,Jennifer Knight-Madden,Tina V. Hartert,Nadia N. Hansel,Marilyn G. Foreman,Jean G. Ford,Mezbah U. Faruque,Georgia M. Dunston,Luis Caraballo,Esteban G. Burchard,Eugene R. Bleecker,Maria Ilma Araujo,Edwin Francisco Herrera-Paz,Monica Campbell,Cassandra Foster,Margaret A. Taub,Terri H. Beaty,Ingo Ruczinski,Rasika A. Mathias,Kathleen C. Barnes,Steven L. Salzberg +46 more
TL;DR: A deeply sequenced dataset of 910 individuals, all of African descent, is used to construct a set of DNA sequences that is present in these individuals but missing from the reference human genome, demonstrating that the African pan-genome contains ~10% more DNA than the current human reference genome.
Journal ArticleDOI
A genome-wide association study on African-ancestry populations for asthma.
Rasika A. Mathias,Audrey V. Grant,Nicholas Rafaels,T. Hand,Li Gao,Candelaria Vergara,Yuhjung J. Tsai,Mao Yang,Monica Campbell,Cassandra Foster,Peisong Gao,Alkis Togias,Nadia N. Hansel,Gregory B. Diette,N. Franklin Adkinson,Mark C. Liu,Mezbah U. Faruque,Georgia M. Dunston,Harold Watson,Michael B. Bracken,Josephine Hoh,Pissamai Maul,Trevor Maul,Anne E. Jedlicka,Tanda Murray,Jacqueline B. Hetmanski,Roxann Ashworth,Chrissie M. Ongaco,Kurt N. Hetrick,Kimberly F. Doheny,Elizabeth W. Pugh,Charles N. Rotimi,Jean G. Ford,Celeste Eng,Esteban G. Burchard,Patrick M. A. Sleiman,Hakon Hakonarson,Erick Forno,Benjamin A. Raby,Scott T. Weiss,Alan F. Scott,Michael Kabesch,Liming Liang,Gonçalo R. Abecasis,Miriam F. Moffatt,William O.C.M. Cookson,Ingo Ruczinski,Terri H. Beaty,Kathleen C. Barnes +48 more
TL;DR: This study illustrates the complexity of identifying true associations for a complex and heterogeneous disease, such as asthma, in admixed populations, especially populations of African descent.
Journal ArticleDOI
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
Rasika A. Mathias,Margaret A. Taub,Christopher R. Gignoux,Wenqing Fu,Shaila Musharoff,Timothy D. O’Connor,Candelaria Vergara,Dara G. Torgerson,Maria Pino-Yanes,Suyash Shringarpure,Lili Huang,Nicholas Rafaels,Meher Preethi Boorgula,Henry Richard Johnston,Victor E. Ortega,Albert M. Levin,Wei Song,Raul Torres,Badri Padhukasahasram,Celeste Eng,Delmy Aracely Mejia-Mejia,Trevor S. Ferguson,Zhaohui S. Qin,Alan F. Scott,Maria Yazdanbakhsh,James G. Wilson,Javier Marrugo,Leslie A. Lange,Rajesh Kumar,Rajesh Kumar,Pedro C. Avila,L. Keoki Williams,Harold Watson,Lorraine B. Ware,Christopher O. Olopade,Olufunmilayo I. Olopade,Ricardo Riccio Oliveira,Carole Ober,Dan L. Nicolae,Deborah A. Meyers,Alvaro Mayorga,Jennifer Knight-Madden,Tina V. Hartert,Nadia N. Hansel,Marilyn G. Foreman,Jean G. Ford,Jean G. Ford,Mezbah U. Faruque,Georgia M. Dunston,Luis Caraballo,Esteban G. Burchard,Eugene R. Bleecker,Maria Ilma Araujo,Edwin Francisco Herrera-Paz,Kimberly Gietzen,Wendy E. Grus,Michael J. Bamshad,Carlos Bustamante,Eimear E. Kenny,Eimear E. Kenny,Ryan D. Hernandez,Ryan D. Hernandez,Terri H. Beaty,Ingo Ruczinski,Joshua M. Akey,Kathleen C. Barnes +65 more
TL;DR: Genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations is presented, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas.
Journal ArticleDOI
FADS genetic variants and ω-6 polyunsaturated fatty acid metabolism in a homogeneous island population.
Rasika A. Mathias,Candelaria Vergara,Li Gao,Nicholas Rafaels,T. Hand,Monica Campbell,Carol A. Bickel,Priscilla Ivester,Susan Sergeant,Kathleen C. Barnes,Floyd H. Chilton +10 more
TL;DR: Findings in a geographically isolated population with a homogenous dietary environment suggest that variants in the Δ-5 desaturase enzymatic step likely regulate the efficiency of conversion of medium-chain PUFAs to potentially inflammatory PUFas, such as AA.
Journal ArticleDOI
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Michelle Daya,Nicholas Rafaels,Tonya M. Brunetti,Sameer Chavan,Albert M. Levin,Aniket Shetty,Christopher R. Gignoux,Meher Preethi Boorgula,Genevieve L. Wojcik,Monica Campbell,Candelaria Vergara,Dara G. Torgerson,Victor E. Ortega,Ayo P. Doumatey,Henry Richard Johnston,Nathalie Acevedo,Maria Ilma Araujo,Pedro C. Avila,Gillian M. Belbin,Eugene R. Bleecker,Carlos Bustamante,Luis Caraballo,Alvaro A. Cruz,Georgia M. Dunston,Celeste Eng,Mezbah U. Faruque,Trevor S. Ferguson,Camila Alexandrina Figueiredo,Jean G. Ford,Weiniu Gan,Pierre-Antoine Gourraud,Nadia N. Hansel,Ryan D. Hernandez,Edwin Francisco Herrera-Paz,Silvia Jiménez,Eimear E. Kenny,Jennifer Knight-Madden,Rajesh Kumar,Leslie A. Lange,Ethan M. Lange,Antoine Lizee,Pissamai Maul,Trevor Maul,Alvaro Mayorga,Deborah A. Meyers,Dan L. Nicolae,Timothy D. O’Connor,Ricardo Riccio Oliveira,Christopher O. Olopade,Olufunmilayo I. Olopade,Zhaohui S. Qin,Charles N. Rotimi,Nicolas Vince,Harold Watson,Rainford J. Wilks,James G. Wilson,Steven L. Salzberg,Carole Ober,Esteban G. Burchard,L. Keoki Williams,Terri H. Beaty,Margaret A. Taub,Ingo Ruczinski,Rasika A. Mathias,Kathleen C. Barnes,Caapa +65 more
TL;DR: A genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA) finds strong evidence for association at four previously reported asthma loci and identifies two potentially African ancestry-specific loci that may be specific to asthma risk in African ancestry populations.