S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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Time-lapse confocal imaging of development of Bacillus anthracis in macrophages.
TL;DR: Time-lapse confocal microscopy is used to follow individual fluorescent spores over time and it is determined that some phagocytized spores survive beyond germination, to become bacilli that then replicate within the macrophages.
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Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys.
Xiankun Zeng,Candace D. Blancett,Keith A. Koistinen,Christopher W. Schellhase,Jeremy J. Bearss,Sheli R. Radoshitzky,Shelley P. Honnold,Taylor B. Chance,Travis K. Warren,Jeffrey W. Froude,Kathleen A. Cashman,John M. Dye,Sina Bavari,Gustavo Palacios,Jens H. Kuhn,Mei G. Sun +15 more
TL;DR: It is demonstrated that promising candidate medical countermeasures may not completely clear EBOV infection in humans, and that a rhesus monkey model may lay the foundation to study EVD sequelae and to develop therapies to abolish E BOV persistence.
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The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus.
Luke D. Jasenosky,Cristhian Cadena,Chad E. Mire,Viktoriya Borisevich,Viraga Haridas,Shahin Ranjbar,Aya Nambu,Sina Bavari,Veronica Soloveva,Supriya Sadukhan,Gail H. Cassell,Thomas W. Geisbert,Sun Hur,Anne E. Goldfeld,Anne E. Goldfeld,Anne E. Goldfeld +15 more
TL;DR: NTZ counteracts varied virus-specific immune evasion strategies by generally enhancing the RNA sensing and interferon axis that is triggered by foreign cytoplasmic RNA exposure, and holds promise as an oral therapy against EBOV.
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HSPA5 is an essential host factor for Ebola virus infection.
St. Patrick Reid,Amy C. Shurtleff,Julie Costantino,Sarah R. Tritsch,Cary Retterer,Kevin B. Spurgers,Sina Bavari +6 more
TL;DR: It is demonstrated that HSPA5 is vital for replication and can serve as a viable target for the design of host-based countermeasures and in vitro and in vivo gene targeting impaired viral replication and protected animals in a lethal infection model.
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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon.
Darci R. Smith,Bradley S. Hollidge,Sharon P. Daye,Xiankun Zeng,Candace D. Blancett,Kyle Kuszpit,Thomas M. Bocan,Jeffrey W. Koehler,Susan R. Coyne,T. D. Minogue,Tara Kenny,Xiaoli Chi,Soojin Yim,Lynn J. Miller,Connie S. Schmaljohn,Sina Bavari,Joseph W. Golden +16 more
TL;DR: This model of ZIKV pathogenesis will be valuable for evaluating medical countermeasures and the pathogenic mechanisms of ZikV because it allows immune responses to be elicited in immunologically competent mice with IFN I blockade only induced at the time of infection.