S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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Journal ArticleDOI
Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway.
Ashwini Brahms,Rajini Mudhasani,Chelsea Pinkham,Krishna P. Kota,Farooq Nasar,Rouzbeh Zamani,Sina Bavari,Kylene Kehn-Hall +7 more
TL;DR: Detailed mechanism-of-action studies indicate that sorafenib causes a disruption in viral egress by targeting VCP and the secretory pathway, resulting in a buildup of virions within dilated ER vesicles.
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Validation of the Filovirus Plaque Assay for Use in Preclinical Studies.
Amy C. Shurtleff,Holly A. Bloomfield,Shannon Mort,Steven A. Orr,Brian Audet,Thomas Whitaker,Michelle J. Richards,Sina Bavari +7 more
TL;DR: The results demonstrated that the EBOV and MARV plaque assays are accurate, precise and robust for filovirus titration in samples associated with the performance of GLP animal model studies.
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Considerations for the development of Zika virus vaccines.
TL;DR: The broader research community’s extensive experience with dengue virus vaccine development and with the pros and cons of different vaccine platforms has led to speculation that a Zika virus vaccine can be accelerated, potentially with clinical trials initiating by the end of 2016.
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Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus Infection
Steven B. Bradfute,Scott M. Anthony,Kelly S. Stuthman,Natarajan Ayithan,Prafullakumar Tailor,Carl I Shaia,Mike Bray,Keiko Ozato,Sina Bavari +8 more
TL;DR: It is reported that VLPs protect Ebola virus-infected mice when given 24 hours post-infection and that the mechanisms of immune protection in this setting require both increased antibody production and generation of cytotoxic T cells, suggesting that a non-replicating Ebola virus vaccine can provide post-exposure protection.
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Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging
Lisa H. Cazares,Sean A. Van Tongeren,Julie Costantino,Tara Kenny,Nicole L. Garza,Ginger Donnelly,Douglas Lane,Rekha G. Panchal,Sina Bavari +8 more
TL;DR: Heat fixation inactivates viral and bacterial pathogens and is compatible with proteomic analysis by MALDI-MSI, which will enable the use of infected tissue from studies performed in bio-safety level 3 laboratories with VEEV and Burkholderia to be safely used for proteomic, small molecule drug detection, and imaging mass spectrometry analysis.