S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
Jeremy Luban,Rachel A. Sattler,Elke Mühlberger,Jason D. Graci,Liangxian Cao,Marla Weetall,Christopher R. Trotta,Joseph M. Colacino,Sina Bavari,Caterina Strambio-De-Castillia,Ellen L Suder,Yetao Wang,Veronica Soloveva,Katherine Cintron-Lue,Nikolai Naryshkin,Mark Pykett,Ellen Welch,Kylie O'Keefe,Ronald Kong,Elizabeth Goodwin,Allan Jacobson,Slobodan Paessler,Stuart W. Peltz +22 more
TL;DR: The anti-COVID-19 potential of PTC299 is described, an orally available compound that is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme of the de novo pyrimidine biosynthesis pathway.
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Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis
Rekha G. Panchal,Bruce L. Geller,Bruce L. Geller,Brett L. Mellbye,Brett L. Mellbye,Douglas Lane,Patrick L. Iversen,Patrick L. Iversen,Sina Bavari +8 more
TL;DR: PPMOs targeting essential genes have the potential of being used as antisense antibiotics to treat B. anthracis infections, according to in vivo and in vitro testing.
Journal ArticleDOI
The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41
TL;DR: It is proposed to delete Rule 3.41 of the International Code of Virus Classification and Nomenclature, which requires the name of a virus taxon to precede the term for the taxonomic unit.
Journal ArticleDOI
Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins
Vitalii Silin,John J. Kasianowicz,Ariel Michelman-Ribeiro,Rekha G. Panchal,Sina Bavari,Joseph W. F. Robertson +5 more
TL;DR: A biosensor for anthrax toxins that was fabricated through the self-assembly of a tBLM with B. anthracis protective antigen ion channels that shows a sensitivity similar to ELISA and can also be used to rapidly screen for molecules that bind to the toxins and potentially inhibit their lethal effects.
Journal ArticleDOI
Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey
Andrew D. Haddow,Unai Pérez-Sautu,Michael R. Wiley,Lynn J. Miller,Adrienne E. Kimmel,Lucia M. Principe,Suzanne E. Wollen-Roberts,Joshua D. Shamblin,Stephanie M. Valdez,Lisa H. Cazares,William D. Pratt,Franco Rossi,Luis A. Lugo-Roman,Sina Bavari,Gustavo Palacios,Aysegul Nalca,Farooq Nasar,M. Louise M. Pitt +17 more
TL;DR: The results indicate that the AGM can be used as a surrogate to model mosquito or sexual ZikV transmission and infection and suggest that AGMs are likely involved in the enzootic maintenance and amplification cycle of ZIKV.