S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin.
James L. Erwin,Luis DaSilva,Sina Bavari,Stephen F. Little,Arthur M. Friedlander,Tran C. Chanh +5 more
TL;DR: Evidence that Bacillus anthracis lethal toxin suppresses rather than induces proinflammatory cytokine production in macrophages is presented, suggesting that LT may contribute to anthrax pathogenesis by suppressing the inflammatory response.
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Identification of small molecule inhibitors of anthrax lethal factor
Rekha G. Panchal,Ann R. Hermone,Tam Luong Nguyen,Thiang Yian Wong,Robert Schwarzenbacher,James J. Schmidt,Douglas Lane,Connor F. McGrath,Benjamin E. Turk,James C. Burnett,M. Javad Aman,Stephen F. Little,Edward A. Sausville,Daniel W. Zaharevitz,Lewis C. Cantley,Robert C. Liddington,Rick Gussio,Sina Bavari +17 more
TL;DR: Six inhibitors of LF are described on the basis of a pharmacophoric relationship determined using X-ray crystallographic data, molecular docking studies and three-dimensional (3D) database mining from the US National Cancer Institute (NCI) chemical repository.
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BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Raymond Taylor,Pravin L. Kotian,Travis K. Warren,Rekha G. Panchal,Sina Bavari,Justin G. Julander,Sylvia Dobo,Angela Rose,Yahya El-Kattan,Brian R. Taubenheim,Y.S. Babu,William P. Sheridan +11 more
TL;DR: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
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Toxicity of staphylococcal enterotoxins potentiated by lipopolysaccharide: major histocompatibility complex class II molecule dependency and cytokine release.
TL;DR: The biological effects of staphylococcal enterotoxins (SE), potentiated by bacterial lipopolysaccharide (LPS), were studied with mice and confirmed that the toxicity of SE was mainly exerted through a mechanism dependent on the expression of major histocompatibility complex class II molecules.
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Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections
Dana L. Swenson,Kelly L. Warfield,Diane L. Negley,Alan L. Schmaljohn,M. Javad Aman,Sina Bavari +5 more
TL;DR: The data indicate that vaccination with GP was required and sufficient to protect against a homologous filovirus challenge, as heterologous wild-type VLPs or hybrid V lPs that did not contain thehomologous GP failed to protect.