S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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Journal ArticleDOI
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
James C. Burnett,James J. Schmidt,Robert G. Stafford,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Jonathan L. Vennerstrom,Connor F. McGrath,Douglas Lane,Edward A. Sausville,Daniel W. Zaharevitz,Rick Gussio,Sina Bavari +12 more
TL;DR: This is the first study to report small molecules (non-peptidics) that inhibit BoNT/A LC metalloprotease activity in the low microM range.
Journal ArticleDOI
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James C. Burnett,Gordon Ruthel,Christian Stegmann,Rekha G. Panchal,Tam Luong Nguyen,Ann R. Hermone,Robert G. Stafford,Douglas Lane,Tara Kenny,Connor F. McGrath,Peter Wipf,Andrea M. Stahl,James J. Schmidt,Rick Gussio,Axel T. Brunger,Sina Bavari +15 more
TL;DR: Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein in a primary culture of embryonic chicken neurons.
Journal ArticleDOI
Identification of a Small-Molecule Entry Inhibitor for Filoviruses
Arnab Basu,Bing Li,Debra M. Mills,Rekha G. Panchal,Steven C. Cardinale,Michelle M. Butler,Norton P. Peet,Helena Majgier-Baranowska,John D. Williams,Ishan Patel,Donald T. Moir,Sina Bavari,Ranjit Ray,Michael Farzan,Lijun Rong,Terry L. Bowlin +15 more
TL;DR: It is hypothesized that compound 7 binds to this hydrophobic pocket at or near the GP1 and GP2 interface and as a consequence inhibits EBOV infection of cells, but the details of the mechanism remain to be determined.
Journal ArticleDOI
Development of engineered vaccines effective against structurally related bacterial superantigens
TL;DR: It is concluded that an optimal combination of these genetically attenuated superantigen vaccines may protect against all structurally related superantigens.
Journal ArticleDOI
Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade
Kelly M. Halverson,Rekha G. Panchal,Tam Luong Nguyen,Rick Gussio,Stephen F. Little,Martin Misakian,Sina Bavari,John J. Kasianowicz +7 more
TL;DR: Electrophysiological measurements demonstrating that full-length LF and EF convert the current-voltage relationship of the heptameric PA63 ion channel from slightly nonlinear to highly rectifying and diode-like at pH 6.6 provides a novel method for characterizing functional toxin interactions.