Sina Bavari

TL;DR: A novel inactivation technique for Zaire Ebola virus (ZEBOV) that uses the photoinduced alkylating probe 1,5-iodonaphthylazide (INA), which is incorporated into lipid bilayers and, when activated by ultraviolet irradiation,Alkylates the proteins therein.

TL;DR: Positively charged PMOs (PMOplus™) are effective for the postexposure protection of two fulminant viral diseases, Ebola and Marburg hemorrhagic fever in nonhuman primates, and this class of antisense agent may also have possibilities for treatment of other viral diseases.

TL;DR: Three-dimensional analyses indicated that half of the originally discovered 1,7-DAAC structure superimposed well with 4-amino-7-chloroquinoline-based antimalarial agents, and this observation led to the discovery that several of the 1, 7- DAAC derivatives are potent in vitro inhibitors of Plasmodium falciparum and, in general, are more efficacious against CQ-resistant strains than against C Q-susceptible strains.

TL;DR: Sphingosine kinase 2 (SK2) is identified as a CHIKV host factor co-localized with the viral replication complex (VRC) during infection and associates with a number of proteins involved in cellular gene expression specifically during viral infection, suggesting a role in replication.

TL;DR: ES-derived motoneurons provide a highly sensitive system that is amenable to large-scale screenings to rapidly identify and evaluate the biological efficacies of novel therapeutics, and suggest that this system is compatible with immunofluorescence-based high-throughput studies.