S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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Functional CD8+ T Cell Responses in Lethal Ebola Virus Infection
TL;DR: A functional and specific, albeit insufficient, adaptive immune response is made in lethal EBOV infection and is protective upon transfer to naive infected recipients, which should cause a change in the current view of the ‘impaired’ immune response to E BOV challenge and may help spark new therapeutic strategies to control lethal filovirus disease.
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Identification of an antioxidant small-molecule with broad-spectrum antiviral activity
Rekha G. Panchal,St. Patrick Reid,Julie P. Tran,Alison A. Bergeron,Jay Wells,Krishna P. Kota,Javad Aman,Sina Bavari +7 more
TL;DR: Small molecule chemical screening for Ebola virus inhibitors resulted in identification of a compound NSC 62914, which was found to exhibit anti-filovirus activity in cell-based assays and in vivo protected mice following challenge with Ebola or Marburg viruses.
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Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A.
TL;DR: These results, combined with an understanding of the molecular nature of superantigen and receptor interactions, indicate that targeting MHC class II binding by site-directed mutagenesis will produce the most effective vaccine.
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Association of ebola virus matrix protein VP40 with microtubules.
Gordon Ruthel,Gretchen L. Demmin,George Kallstrom,Melodi P. Javid,Shirin S. Badie,Amy B. Will,Timothy Nelle,Rowena D Schokman,Tam Luong Nguyen,John H. Carra,Sina Bavari,M. Javad Aman +11 more
TL;DR: It is reported that Ebola virus associates with microtubules via the matrix protein VP40, and an in vitro polymerization assay demonstrated that VP40 directly enhances tubulin polymerization without any cellular mediators.
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Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice.
Krishnamurthy Konduru,Steven B. Bradfute,Jerome Jacques,Mohanraj Manangeeswaran,Siham Nakamura,Sufi Morshed,Steven C. Wood,Sina Bavari,Gerardo G. Kaplan +8 more
TL;DR: Results show that vaccination with the ZEBOVGP-Fc fusion protein alone without the need of a viral vector or assembly into virus-like particles is sufficient to induce protective immunity against ZE BOV in mice.