Sina Bavari

TL;DR: The updated taxonomy of the order Mononegavirales is presented as now accepted by the International Committee on Taxonomy of Viruses (ICTV).

TL;DR: All bacterial superantigens use common structural strategies to bind to major histocompatibility complex class II receptors, while binding the T cell antigen receptor in different ways.

TL;DR: It is shown for the first time that hepatocyte apoptosis likely occurs in EBOV infection, and that mice lacking the proapoptotic genes Bim and Bid had reduced hepatocytes apoptosis and liver enzyme levels postinfection, which suggest that hepatocytes may play a role in the pathogenesis of EBOv infection, whereas lymphocyte apoptotic pathway appears to be nonessential for E BOV disease progression.

TL;DR: The results provide a model for arenavirus polymerase–template interactions and reveal the structural organization of a negative-strand RNA virus L protein.

TL;DR: In a murine model of ZEBOV infection, delivery of FGI-103 reduces viremia and the viral burden in kidney, liver, and spleen tissues and is associated with subdued and delayed proinflammatory cytokine responses and tissue pathology, which identify a promising antiviral therapeutic candidate for the treatment of filovirus infections.