S
Sina Bavari
Researcher at United States Army Medical Research Institute of Infectious Diseases
Publications - 353
Citations - 21495
Sina Bavari is an academic researcher from United States Army Medical Research Institute of Infectious Diseases. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 69, co-authored 349 publications receiving 18782 citations. Previous affiliations of Sina Bavari include University of Nebraska Medical Center & Walter Reed Army Institute of Research.
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SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons.
Erkan Kiris,James C. Burnett,Jonathan E. Nuss,Laura M. Wanner,Brian D. Peyser,Hao T. Du,Glenn Y. Gomba,Krishna P. Kota,Rekha G. Panchal,Rick Gussio,Christopher D. Kane,Lino Tessarollo,Sina Bavari +12 more
TL;DR: This study explored how modulation of key host pathways affects the process of BoNT intoxication in human motor neurons, focusing on Src family kinase (SFK) signaling, and highlighted the importance of targeting host neuronal pathways, rather than the toxin’s enzymatic components, to antagonize multiple BoNT serotypes in motor neurons.
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Glucopyranosyl lipid adjuvant enhances immune response to Ebola virus-like particle vaccine in mice
Melek M. E. Sunay,Karen A. Martins,Jesse T. Steffens,Melissa K. Gregory,Sean A. Vantongeren,Neal Van Hoeven,Preston G. Garnes,Sina Bavari +7 more
TL;DR: GLA-SE enhanced EBOV-specific immunity and resulted in long-term protection against challenge with ma-EBOV infection in a mouse model, providing further support for the utility of TLR4 activating GLA- SE-adjuvanted vaccines.
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Development and characterization of rabbit and mouse antibodies against ebolavirus envelope glycoproteins
Wu Ou,Josie Delisle,Krishnamurthy Konduru,Steven B. Bradfute,Sheli R. Radoshitzky,Cary Retterer,Krishna P. Kota,Sina Bavari,Jens H. Kuhn,Peter B. Jahrling,Gerardo G. Kaplan,Carolyn A. Wilson +11 more
TL;DR: A panel of antibodies that either cross-react or are virus-specific are developed and may prove useful for both in vitro analyses of ebolavirus GP₁,₂, as well as analysis of clinically relevant samples are suggested.
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Induced IL-10 splice altering approach to antiviral drug discovery.
Rekha G. Panchal,Dan V. Mourich,Steven B. Bradfute,Laura L. Hauck,Kelly L. Warfield,Patrick L. Iversen,Sina Bavari +6 more
TL;DR: It is shown that resistance to ebola infection is regulated by IL-10 and can be targeted in a prophylactic manner to protect against lethal hemorrhagic virus challenge.
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Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis.
Rekha G. Panchal,Gordon Ruthel,Katherine C. Brittingham,Douglas Lane,Tara Kenny,Rick Gussio,John S. Lazo,Sina Bavari +7 more
TL;DR: It is proposed that induction of antiapoptotic responses by MAPK-dependent or -independent pathways and activation of host innate responses may protect macrophages from anthrax LT-induced cell death.