M
Michael Segel
Researcher at University of Cambridge
Publications - 10
Citations - 1890
Michael Segel is an academic researcher from University of Cambridge. The author has contributed to research in topics: Microglia & Remyelination. The author has an hindex of 8, co-authored 10 publications receiving 947 citations.
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Journal ArticleDOI
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
Timothy R. Hammond,Timothy R. Hammond,Timothy R. Hammond,Connor Dufort,Lasse Dissing-Olesen,Lasse Dissing-Olesen,Lasse Dissing-Olesen,Stefanie Giera,Stefanie Giera,Adam Young,Alec Wysoker,Alec J. Walker,Alec J. Walker,Alec J. Walker,Frederick Gergits,Michael Segel,James Nemesh,Samuel E. Marsh,Samuel E. Marsh,Samuel E. Marsh,Arpiar Saunders,Arpiar Saunders,Evan Z. Macosko,Florent Ginhoux,Jinmiao Chen,Robin J.M. Franklin,Xianhua Piao,Xianhua Piao,Steven A. McCarroll,Steven A. McCarroll,Beth Stevens +30 more
TL;DR: The analysis of RNA expression patterns of more than 76,000 individual microglia in mice during development, in old age, and after brain injury uncovered at least nine transcriptionally distinct microglial states, which expressed unique sets of genes and were localized in the brain using specific markers.
Journal ArticleDOI
Niche stiffness underlies the ageing of central nervous system progenitor cells.
Michael Segel,Björn Neumann,Myfanwy Hill,Isabell P. Weber,Carlo Viscomi,Chao Zhao,Adam Young,Chibeza C. Agley,Amelia J Thompson,Ginez A. Gonzalez,Amar Sharma,Staffan Holmqvist,David H. Rowitch,Kristian Franze,Robin J.M. Franklin,Kevin J. Chalut +15 more
TL;DR: It is shown that tissue stiffness is a crucial regulator of ageing in OPCs, and insights into how the function of adult stem and progenitor cells changes with age are provided.
Journal ArticleDOI
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
Björn Neumann,Roey Baror,Chao Zhao,Michael Segel,Sabine Dietmann,Khalil S. Rawji,Sarah Foerster,Crystal R. McClain,Kevin J. Chalut,Peter van Wijngaarden,Peter van Wijngaarden,Robin J.M. Franklin +11 more
TL;DR: Insight is provided into aging-associated remyelination failure and therapeutic interventions for reversing such declines in chronic disease are suggested, suggesting synergistic effects of rejuvenation and pro-differentiation therapies.
Journal ArticleDOI
A map of transcriptional heterogeneity and regulatory variation in human microglia.
Adam Young,Adam Young,Natsuhiko Kumasaka,Fiona Calvert,Timothy R. Hammond,Timothy R. Hammond,Andrew J Knights,Nikolaos Panousis,Jun Sung Park,Jeremy Schwartzentruber,Jimmy Z. Liu,Kousik Kundu,Michael Segel,Natalia A. Murphy,Christopher E McMurran,Harry Bulstrode,Jason Correia,Karol P. Budohoski,Alexis J Joannides,Mathew R. Guilfoyle,Rikin A. Trivedi,Ramez W. Kirollos,Robert H. Morris,Matthew R. Garnett,Ivan Timofeev,Ibrahim Jalloh,Katherine Holland,Richard Mannion,Richard Mair,Colin Watts,Stephen J. Price,Peter J. Kirkpatrick,Thomas Santarius,Edward Mountjoy,Maya Ghoussaini,Nicole Soranzo,Omer Ali Bayraktar,Beth Stevens,Beth Stevens,Peter J. Hutchinson,Robin J.M. Franklin,Daniel J. Gaffney +41 more
TL;DR: In this paper, gene expression variation in primary human microglia isolated from 141 patients undergoing neurosurgery was profiled using expression quantitative trait loci (eQTL) mapping.
Posted ContentDOI
A map of transcriptional heterogeneity and regulatory variation in human microglia
Adam Mh Young,Natsuhiko Kumasaka,Fiona Calvert,Timothy R. Hammond,Andrew J Knights,Nikolaos Panousis,Jeremy Schwartzentruber,Jimmy Z. Liu,Kousik Kundu,Michael Segel,Natalia A. Murphy,Christopher E McMurran,Harry Bulstrode,Jason Correia,Karol P. Budohoski,Alexis J Joannides,Mathew R. Guilfoyle,Rikin A. Trivedi,Ramez W. Kirollos,Robert H. Morris,Matthew R. Garnett,Helen M Fernandes,Ivan Timofeev,Ibrahim Jalloh,Katherine Holland,Richard Mannion,Richard Mair,Colin Watts,Stephen J. Price,Peter J. Kirkpatrick,Thomas Santarius,Nicole Soranzo,Beth Stevens,Peter J. Hutchinson,Robin J.M. Franklin,Daniel J. Gaffney +35 more
TL;DR: This study provides the first population-scale transcriptional map of a critically important cell for neurodegenerative disorders and fine-map candidate causal variants at risk loci for Alzheimer’s disease.