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Stefan Jordan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 11
Citations - 1417
Stefan Jordan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 10, co-authored 11 publications receiving 939 citations.
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Journal ArticleDOI
Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.
Hélène Salmon,Juliana Idoyaga,Adeeb Rahman,Marylene Leboeuf,Romain Remark,Stefan Jordan,Maria Casanova-Acebes,Makhzuna Khudoynazarova,Judith Agudo,Navpreet Tung,Svetoslav Chakarov,Christina Rivera,Brandon Hogstad,Marcus Bosenberg,Daigo Hashimoto,Sacha Gnjatic,Nina Bhardwaj,Anna Karolina Palucka,Brian D. Brown,Joshua Brody,Florent Ginhoux,Miriam Merad +21 more
TL;DR: The paucity of activated CD103(+) DCs in tumors limits checkpoint-blockade efficacy and combined FLT3L and poly I:C therapy can enhance tumor responses to checkpoint and BRAF blockade.
Journal ArticleDOI
Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool
Stefan Jordan,Navpreet Tung,Maria Casanova-Acebes,Christie Chang,Claudia Cantoni,Dachuan Zhang,Theresa H. Wirtz,Shruti Naik,Samuel A. Rose,Chad Brocker,Anastasiia Gainullina,Anastasiia Gainullina,Daniel Hornburg,Sam Horng,Barbara Maier,Paolo Cravedi,Derek LeRoith,Frank J. Gonzalez,Felix Meissner,Jordi Ochando,Adeeb Rahman,Jerry E. Chipuk,Maxim N. Artyomov,Paul S. Frenette,Laura Piccio,Laura Piccio,Marie-Luise Berres,Emily J. Gallagher,Miriam Merad +28 more
TL;DR: It is shown that fasting improves chronic inflammatory diseases without compromising monocyte emergency mobilization during acute infectious inflammation and tissue repair and that caloric intake and liver energy sensors dictate the blood and tissue immune tone and link dietary habits to inflammatory disease outcome.
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Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.
Alex Rialdi,Laura Campisi,Nan Zhao,Arvin Cesar Lagda,Colette Pietzsch,Jessica Sook Yuin Ho,Luis Martínez-Gil,Luis Martínez-Gil,Romain Fenouil,Xiaoting Chen,Megan R. Edwards,Giorgi Metreveli,Stefan Jordan,Zuleyma Peralta,César Muñoz-Fontela,Nicole M. Bouvier,Miriam Merad,Jian Jin,Matthew T. Weirauch,Sven Heinz,Sven Heinz,Christopher Benner,Harm van Bakel,Christopher F. Basler,Adolfo García-Sastre,Alexander Bukreyev,Ivan Marazzi +26 more
TL;DR: Chemical inhibition of topoisomerase 1 (Top1), an enzyme that unwinds DNA, suppresses the expression of infection-induced genes with little to no effect on housekeeping gene expression and without cellular damage, is found.
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Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
Christoph Hirche,Theresa Frenz,Simon Haas,Marius Döring,Katharina Borst,Pia K. Tegtmeyer,Ilija Brizić,Stefan Jordan,Kirsten A. Keyser,Chintan Chhatbar,Eline Pronk,Shuiping Lin,Martin Messerle,Stipan Jonjić,Christine S. Falk,Andreas Trumpp,Marieke A.G. Essers,Ulrich Kalinke +17 more
TL;DR: The results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants.
Journal ArticleDOI
RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.
Brandon Hogstad,Marie-Luise Berres,Marie-Luise Berres,Rikhia Chakraborty,Rikhia Chakraborty,Jun Tang,Jun Tang,Camille Bigenwald,Madhavika N. Serasinghe,Karen Phaik Har Lim,Karen Phaik Har Lim,Howard Lin,Howard Lin,Tsz-Kwong Man,Tsz-Kwong Man,Romain Remark,Samantha Baxter,Veronika Kana,Stefan Jordan,Zoi Karoulia,Wing-hong Kwan,Marylene Leboeuf,EF Brandt,Hélène Salmon,Kenneth L. McClain,Kenneth L. McClain,Poulikos I. Poulikakos,Jerry E. Chipuk,Willem J. M. Mulder,Carl E. Allen,Carl E. Allen,Miriam Merad +31 more
TL;DR: Results indicate that MAPK tightly suppresses DC migration and augments DC survival, rendering DCs in LCH lesions trapped and resistant to cell death.