S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
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An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component
TL;DR: Promiscuous interactions of the intrinsically disordered Rnq1 prion protein with the spindle pole body component Spc 42 result in Spc42’s sequestration in insoluble bodies and cell cycle arrest.
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The Peptidyl-prolyl Isomerase Domain of the CyP-40 Cyclophilin Homolog Cpr7 Is Not Required to Support Growth or Glucocorticoid Receptor Activity in Saccharomyces cerevisiae*
Andrea A. Duina,James A. Marsh,Richard B. Kurtz,Hui Chen Jane Chang,Susan Lindquist,Richard F. Gaber +5 more
TL;DR: Results indicate that the TPR-containing carboxyl terminus of Cpr7 is sufficient for fundamental CPR7-dependent activity, and deletion of the entire PPIase domain did not significantly affect growth or Hsp90-mediated steroid receptor activity.
Nontoxic antimicrobials that evade drug resistance
Stephen Davis,Benjamin Vincent,Matthew M. Endo,Luke Whitesell,Karen Marchillo,David R. Andes,Susan Lindquist,Martin D. Burke +7 more
TL;DR: Surprisingly, exhaustive efforts to select for mutants resistant to these more selective compounds revealed that they are just as impervious to resistance as AmB, suggesting practical routes to the discovery of less toxic, resistance-evasive therapies.
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Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers
Peter Tsvetkov,Ethan S. Sokol,Dexter X. Jin,Zarina Brune,Prathapan Thiru,Mahmoud Ghandi,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Piyush Gupta,Sandro Santagata,Luke Whitesell,Susan Lindquist,Susan Lindquist +13 more
TL;DR: Analysis of data from thousands of cancer lines and tumors finds that those with suppressed expression of one or more 19S proteasome subunits show intrinsic proteasomesome inhibitor resistance, and this mechanism is associated with poor outcome in myeloma patients.
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Combating neurodegenerative disease with chemical probes and model systems
TL;DR: The seminal role that chemical biology has played in furthering the research on and treatment of dysfunctional proteinHomeostasis in NDs is reviewed and the vital and predictive role of model systems in identifying conserved homeostasis pathways and genes therein that are altered in neurodegeneration is discussed.