S
Susan Lindquist
Researcher at Massachusetts Institute of Technology
Publications - 443
Citations - 86482
Susan Lindquist is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Heat shock protein & Saccharomyces cerevisiae. The author has an hindex of 147, co-authored 440 publications receiving 81067 citations. Previous affiliations of Susan Lindquist include University of Illinois at Chicago & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Widespread inhibition of posttranscriptional splicing shapes the cellular transcriptome following heat shock.
TL;DR: Widespread repression of splicing is demonstrated in the mammalian heat stress response, disproportionately affecting posttranscriptionally spliced genes.
Journal ArticleDOI
Creating a Protein-Based Element of Inheritance
Liming Li,Susan Lindquist +1 more
TL;DR: The complete change in phenotype achieved by transferring a prion determinant from one protein to another confirms the protein-only nature of prion inheritance and establishes a mechanism for engineering heritable changes in phenotype that should be broadly applicable.
Journal ArticleDOI
An Arabidopsis heat shock protein complements a thermotolerance defect in yeast.
TL;DR: The ability of AtHSP101 to protect yeast from severe heat stress strongly suggests that this HSP plays an important role in thermotolerance in higher plants.
A Yeast Model of FUS/TLS-Dependent Cytotoxicity
Shulin Ju,Daniel F. Tardiff,Haesun Han,Kanneganti Divya,Quan Zhong,Lynne E. Maquat,Daryl A. Bosco,Lawrence J. Hayward,Robert H. Brown,Susan Lindquist,Dagmar Ringe,Dagmar Ringe,Gregory A. Petsko,Gregory A. Petsko +13 more
TL;DR: A yeast model of human FUS/TLS expression is reported that recapitulates multiple salient features of the pathology of the disease-causing mutant proteins, including nuclear to cytoplasmic translocation, inclusion formation, and cytotoxicity, validating the yeast model and implicating a possible insufficiency in RNA processing or the RNA quality control machinery.
Journal ArticleDOI
Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion
TL;DR: In this article, a prion formed by the Mot3 transcription factor, [MOT3 + ], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces cerevisiae.